产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
Canine Complement Component 3B ELISA Kit
目录 :
MBS033964
规格 :
48-Strip-Wells
价格 :
435美元
更多信息或购买 :
产品信息
目录号 :
MBS033964
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
Canine Complement Component 3B ELISA Kit
产品简称 :
Complement Component 3B
其他名称 :
complement receptor type 1 isoform S; Complement receptor type 1; complement receptor type 1; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component (3b/4b) receptor 1 (Knops blood group); C3b/C4b receptor
产品基因名称 :
C3B
其他基因名称 :
CR1;CR1;KN;C3BR;C4BR;CD35;C3BR
UniProt数据库进入名 :
CR1_HUMAN
反应物种 :
序列长度 :
2489
特异性 :
No significant cross-reactivity or interference between Canine C3B and analogues was observed.
储存稳定性 :
Store all reagents at 2-8 degree C
其它信息1 :
Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 31.2 mug/ml - 1000 mug/ml. Sensitivity: 5.0 mug/ml.
其他信息2 :
Intended Uses: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated C3B concentrations in Canine serum, plasma and other body fluids. Using Purified Canine C3B antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add C3B and C3B antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of C3B in the samples is then determined by comparing the O.D. of the samples to the standard curve. Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]
产品描述 :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated C3B concentrations in Canine serum, plasma and other body fluids. Using Purified Canine C3B antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add C3B and C3B antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of C3B in the samples is then determined by comparing the O.D. of the samples to the standard curve.
NCBI GI登录号 :
86793109
NCBI登录号 :
NP_000642.3
NCBI基因登录号 :
NM_000651.4
UniProt数据库登录号 :
P17927
NCBI分子量 :
223,663 Da
NCBI信号通路 :
Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (106386); Innate Immune System Pathway (106387); Legionellosis Pathway (469200); Legionellosis Pathway (469186)
NCBI总结 :
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; complement component C3b binding. Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway. Disease: Knops Blood Group System; Malaria, Susceptibility To
尺寸1 :
48-Strip-Wells
价格1 :
435美元
尺寸2 :
96-Strip-Wells
价格2 :
600
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。