ELISA/assay

鱼类毒蕈碱型乙酰胆碱受体酶联免疫吸附试剂盒

MBS038232

48-Strip-Wells

435美元

酶联免疫吸附试剂盒

鱼类毒蕈碱型乙酰胆碱受体酶联免疫吸附试剂盒

毒蕈碱型乙酰胆碱受体

毒蕈碱型乙酰胆碱受体M1;毒蕈碱型乙酰胆碱受体M1;毒蕈碱型乙酰胆碱受体M1;乙酰胆碱受体, 毒蕈碱1;胆碱能受体, 毒蕈碱1

M-ACHR

CHRM1;CHRM1;M1;HM1;M1R

ACM1_HUMAN

Fish

460

No significant cross-reactivity or interference between Fish M-ACHR and analogues was observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate M-ACHR concentrations in Fish serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!

37622910

NP_000729.2

NM_000738.2

P11229

51,421 Da

Amine Ligand-binding Receptors Pathway (106363); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cholinergic Synapse Pathway (217716); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886)

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

mAChR m1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: asymmetric synapse; postsynaptic membrane; membrane; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; nerve terminal; cell junction. Molecular Function: drug binding; phosphoinositide phospholipase C activity; G-protein coupled acetylcholine receptor activity. Biological Process: nervous system development; acetylcholine receptor signaling, muscarinic pathway; protein modification process; signal transduction; muscarinic acetylcholine receptor, phospholipase C activating pathway; regulation of locomotion; G-protein coupled receptor protein signaling pathway; cell proliferation; protein kinase C activation; positive regulation of cell proliferation; neuromuscular synaptic transmission; positive regulation of ion transport; cognition; saliva secretion

48-Strip-Wells

435美元

96-Strip-Wells

600