产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
大鼠整合素甲M酶联免疫吸附试剂盒
目录 :
MBS100015
规格 :
48-Strip-Wells
价格 :
435美元
更多信息或购买 :
产品信息
目录号 :
MBS100015
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
大鼠整合素甲M酶联免疫吸附试剂盒
产品简称 :
整合素甲M
其他名称 :
integrin alpha-M isoform 1; Integrin alpha-M; integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit; integrin, alpha M (complement component 3 receptor 3 subunit); CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
产品基因名称 :
ITGalphaM
其他基因名称 :
ITGAM;ITGAM;CR3A;MO1A;CD11B;MAC-1;MAC1A;SLEB6;CD11B;CR3A
UniProt数据库进入名 :
ITAM_HUMAN
反应物种 :
大鼠
序列长度 :
1153
特异性 :
No significant cross-reactivity or interference between Rat ITGalphaM and analogues was observed.
储存稳定性 :
Store all reagents at 2-8 degree C
其它信息1 :
Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.
其他信息2 :
Intended Uses: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated ITGalphaM concentrations in Rat serum, plasma and other body fluids. Using Purified Rat ITGalphaM antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add ITGalphaM and ITGalphaM antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of ITGalphaM in the samples is then determined by comparing the O.D. of the samples to the standard curve. Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]
产品描述 :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated ITGalphaM concentrations in Rat serum, plasma and other body fluids. Using Purified Rat ITGalphaM antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add ITGalphaM and ITGalphaM antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of ITGalphaM in the samples is then determined by comparing the O.D. of the samples to the standard curve.
NCBI GI登录号 :
224831239
NCBI登录号 :
NP_001139280.1
NCBI基因登录号 :
NM_001145808.1
UniProt数据库登录号 :
P11215
NCBI分子量 :
127,179 Da
NCBI信号通路 :
Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (106028)
NCBI总结 :
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt数据库总结 :
Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Subunit structure: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3. Ref.10 Ref.11. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Predominantly expressed in monocytes and granulocytes. Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. Involvement in disease: Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Sequence similarities: Belongs to the integrin alpha chain family.Contains 7 FG-GAP repeats.Contains 1 VWFA domain.
尺寸1 :
48-Strip-Wells
价格1 :
435美元
尺寸2 :
96-Strip-Wells
价格2 :
600
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。