蛋白

Recombinant Human N-glycosylase/DNA lyase

MBS1151639

0.01毫克(酵母)

125美元

重组蛋白

Recombinant Human N-glycosylase/DNA lyase

N-glycosylase/DNA lyase

Including the following 2 domains: 8-oxoguanine DNA glycosylase (EC:3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18); AP lyase

N-glycosylase/DNA lyase isoform 1a; N-glycosylase/DNA lyase; N-glycosylase/DNA lyase; 8-oxoguanine DNA glycosylase

OGG1

OGG1;OGG1;HMMH;MUTM;OGH1;HOGG1;MMH;MUTM;OGH1;ap裂解酶

OGG1_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-345

345

MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVL
PSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVY
RGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVD
SHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARIT
GMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAH
LRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYE
EAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWH
IAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAG
WAQAVLFSADLRQCRHAQEPPAKRRKGSKGPEG

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Species: Homo sapiens (Human)

Cancer

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue." Aburatani H., Hippo Y., Ishida T., Takashima R., Matsuba C., Kodama T., Takao M., Yasui A., Yamamoto K., Asano M., Fukasawa K., Yoshinari T., Inoue H., Otsuka E., Nishimura S. Cancer Res. 57:2151-2156(1997)

4505495

NP_002533.1

NM_002542.5

O15527

42.05kD

APEX1-Independent Resolution Of AP Sites Via The Single Nucleotide Replacement Pathway (1270363); Base Excision Repair Pathway (1270351); Base Excision Repair Pathway (83043); Base Excision Repair Pathway (451); Base-Excision Repair, AP Site Formation Pathway (1270352); Cleavage Of The Damaged Purine Pathway (1270355); Cleavage Of The Damaged Pyrimidine Pathway (1270358); DNA Repair Pathway (1270350); Depurination Pathway (1270353); Depyrimidination Pathway (1270356)

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

OGG1: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Belongs to the type-1 OGG1 family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Lyase; DNA repair, damage; EC 4.2.99.18; Deoxyribonuclease. Chromosomal Location of Human Ortholog: 3p26.2. Cellular Component: mitochondrion; nuclear matrix; nuclear speck; nucleoplasm; nucleus; protein complex. Molecular Function: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; damaged DNA binding; endonuclease activity; microtubule binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; protein binding. Biological Process: acute inflammatory response; aging; base-excision repair; base-excision repair, AP site formation; depurination; depyrimidination; DNA repair; negative regulation of apoptosis; nucleotide-excision repair, DNA incision; regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to folic acid; response to light stimulus; response to oxidative stress; response to radiation. Disease: Renal Cell Carcinoma, Nonpapillary

0.01毫克(酵母)

125美元

0.05毫克(大肠杆菌)

165

0.05毫克(酵母)

220

0.2毫克(大肠杆菌)

385

0.2毫克(酵母)

560