抗体

小鼠单克隆抗体抗人类CBP

MBS120014

0.1毫克

345美元

单克隆

小鼠

未共轭

CBP5I001

免疫印迹, 免疫细胞化学, 免疫沉淀

抗体

小鼠单克隆抗体抗人类CBP

CBP

CREB结合蛋白(CBP)

Human CREB-binding protein (CBP) mRNA, complete cds; CREB-binding protein; CREB binding protein

CBP

CREBBP;CBP;RSTS;KAT3A

单克隆

IgG1

CBP5I001

小鼠

人类

8694

100微克/毫升(1.0毫升)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. CREBBP, as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. [UniProtKB Function]

2443858

AAC51770.1

U47741

Activation Of Gene Expression By SREBF (SREBP) Pathway (685552); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Androgen Receptor Signaling Pathway (198806); Angiogenesis Pathway (198772); Attenuation Phase Pathway (1127556); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); C-MYB Transcription Factor Network Pathway (138073); Cell Cycle Pathway (83054); Cell Cycle Pathway (463)

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

CBP: a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1; the interaction results in acetylation of KLF1 and enhancement of its transcriptional activity. Interacts with ZCCHC12. Interacts with DAXX; the interaction is dependent on CBP sumoylation and results in suppression of the transcriptional activiy via recruitment of HDAC2 to DAAX. Interacts with MTDH. Interacts with NFATC4. Interacts with MAFG; the interaction acetylates MAFG in the basic region and stimulates NFE2 transcriptional activity through increasing its DNA-binding activity. Interacts with IRF2; the interaction acetylates IRF2 and regulates its activity on the H4 promoter. Interacts via its N-terminus with the C-terminus of SS18L1. Interacts with MECOM. Chromosomal aberrations involving CBP may be a cause of acute myeloid leukemias. Known translocation partners include MYST3, MLL, and MYST4. MYST3-CBP fusion proteins may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1), an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. Protein type: Motility/polarity/chemotaxis; DNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator; EC 2.3.1.48; Acetyltransferase. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: nucleoplasm; nuclear body; transcription factor complex; nuclear chromatin; cytoplasm; outer kinetochore of condensed chromosome; nucleus; histone acetyltransferase complex. Molecular Function: MRF binding; protein binding; signal transducer activity; histone acetyltransferase activity; zinc ion binding; p53 binding; acetyltransferase activity; transcription coactivator activity; chromatin binding; transcription factor activity; transcription factor binding. Biological Process: transcription initiation from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; Notch signaling pathway; viral reproduction; positive regulation of transcription, DNA-dependent; rhythmic process; germ-line stem cell maintenance; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; homeostatic process; regulation of transcription, DNA-dependent; positive regulation of interferon type I production; response to hypoxia; innate immune response; gene expression; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; histone acetylation; embryonic digit morphogenesis; regulation of smoothened signaling pathway; N-terminal peptidyl-lysine acetylation. Disease: Rubinstein-taybi Syndrome 1

0.1毫克

345美元