抗体

小鼠单克隆抗体抗人类IRF3

MBS120017

0.1毫克

345美元

单克隆

小鼠

未共轭

IRF35I218

免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 流式细胞仪

抗体

小鼠单克隆抗体抗人类IRF3

IRF3

干扰素调节因子3

人干扰素调节因子3, mRNA;干扰素调节因子3;干扰素调节因子3;干扰素调节因子3

IRF3

IRF3;IRF3

IRF3_HUMAN

单克隆

IgG1

IRF35I218

小鼠

人类

1716

100微克/毫升(1.0毫升)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [NCBI Entrez Gene Summary]

47940513

BC071721

12,330 Da

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (366171); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115)

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; negative regulation of interferon-beta biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; negative regulation of defense response to virus by host; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; response to exogenous dsRNA; positive regulation of interferon type I production; positive regulation of interferon-beta production; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; innate immune response; interferon type I biosynthetic process; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production; defense response to virus; response to DNA damage stimulus; positive regulation of interferon-alpha production; positive regulation of cytokine secretion. Disease: Herpes Simplex Encephalitis, Susceptibility To, 7

0.1毫克

345美元