抗体

小鼠单克隆抗体抗人类视网膜成神经细胞瘤相关蛋白

MBS120046

0.1毫克

345美元

单克隆

小鼠

nonconjugated

RB1AD56A

酶联免疫吸附测定, 免疫细胞化学, 酶免疫法

抗体

小鼠单克隆抗体抗人类视网膜成神经细胞瘤相关蛋白

视网膜成神经细胞瘤相关蛋白

视网膜母细胞瘤1(包括骨肉瘤)(视网膜成神经细胞瘤相关蛋白);RB;OSRC

Homo sapiens retinoblastoma 1 (RB1), mRNA; Retinoblastoma-associated protein; retinoblastoma-associated protein; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; retinoblastoma suspectibility protein; retinoblastoma 1; p105-Rb; pRb; Rb; pp110

视网膜成神经细胞瘤相关蛋白

RB1; RB1; RB; pRb; OSRC; pp110; p105-Rb; PPP1R130

RB_HUMAN

单克隆

IgG1

RB1AD56A

小鼠

人类

4772

100微克/毫升(1.0毫升)

Dot Blot (DB), ELISA (EIA), Immunocytochemistry (ICC)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.[supplied by OMIM] [NCBI Entrez Gene Summary]

108773786

NP_000312.2

NM_000321

106,159 Da

Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); B Cell Receptor Signaling Pathway (198909); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463)

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Rb: retinoblastoma tumor suppressor protein regulates cell proliferation by controlling progression through the G1-phase restriction point. Has three distinct binding domains and interacts with regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif. Cell cycle-dependent phosphorylation by Cdks inhibits Rb target binding, thus allowing cell cycle progression. Recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression. Protein type: Tumor suppressor; Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 13q14.2. Cellular Component: nucleoplasm; SWI/SNF complex; PML body; Rb-E2F complex; spindle; chromatin; nucleus. Molecular Function: identical protein binding; protein binding; DNA binding; androgen receptor binding; ubiquitin protein ligase binding; transcription coactivator activity; phosphoprotein binding; kinase binding; transcription factor binding; transcription factor activity. Biological Process: sister chromatid biorientation; viral reproduction; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter, mitotic; regulation of mitotic cell cycle; neuron maturation; positive regulation of macrophage differentiation; cell cycle arrest; neurite development; negative regulation of epithelial cell proliferation; transcription, DNA-dependent; mitotic cell cycle checkpoint; negative regulation of transcription factor activity; enucleate erythrocyte differentiation; regulation of lipid kinase activity; myoblast differentiation; chromatin remodeling; G1/S-specific transcription in mitotic cell cycle; neuron apoptosis; maintenance of mitotic sister chromatid cohesion; gut development; cell division; negative regulation of smoothened signaling pathway; neuron morphogenesis during differentiation; androgen receptor signaling pathway; Ras protein signal transduction; positive regulation of mitotic metaphase/anaphase transition; striated muscle cell differentiation; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; negative regulation of transcription, DNA-dependent; cell cycle checkpoint; G1/S transition of mitotic cell cycle. Disease: Bladder Cancer; Osteogenic Sarcoma; Small Cell Cancer Of The Lung; Retinoblastoma

0.1毫克

345美元