产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
小鼠单克隆抗体抗人类ASXL1
目录 :
MBS120126
规格 :
0.1毫克
价格 :
345美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2049C2a
反应物种 :
人类
应用 :
免疫印迹, dot blot
更多信息或购买 :
文章摘录数: 1
参考文献
Inoue D, Matsumoto M, Nagase R, Saika M, Fujino T, Nakayama K, et al. Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels. Exp Hematol. 2016;44:172-6.e1 pubmed 出版商
产品信息
目录号 :
MBS120126
产品类型 :
抗体
产品全称 :
小鼠单克隆抗体抗人类ASXL1
产品简称 :
ASXL1
产品名称同义词 :
Homo sapiens additional sex combs like 1 (Drosophila) (ASXL1), mRNA; KIAA0978; MGC71111; MGC117280
其他名称 :
Homo sapiens additional sex combs like transcriptional regulator 1 (ASXL1), transcript variant 1, mRNA; Putative Polycomb group protein ASXL1; putative Polycomb group protein ASXL1; additional sex combs like 1; additional sex combs like transcriptional regulator 1; Additional sex combs-like protein 1
产品基因名称 :
ASXL1
其他基因名称 :
ASXL1;ASXL1;MDS;BOPS
UniProt数据库进入名 :
ASXL1_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
2049C2a
宿主 :
小鼠
反应物种 :
人类
序列长度 :
7056
浓度 :
100微克/毫升(1.0毫升)
检测过的应用 :
Dot Blot (DB)
其它信息1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
其他信息2 :
Sterility: Filtered through a 0.22 um membrane.
产品描述 :
In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. Although the function of the protein encoded by this gene is not known, it does show some sequence similarity to the protein encoded by the Drosophila Asx gene. [NCBI Entrez Gene Summary]
NCBI GI登录号 :
257195176
NCBI登录号 :
NP_056153.2
NCBI基因登录号 :
NM_015338
NCBI分子量 :
53,374 Da
NCBI总结 :
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
UniProt数据库总结 :
ASXL1: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at Lys-119 (H2AK119ub1). Defects in ASXL1 are the cause of Bohring-Opitz syndrome (BOPS). A syndrome characterized by severe intrauterine growth retardation, poor feeding, profound mental retardation, trigonocephaly, prominent metopic suture, exophthalmos, nevus flammeus of the face, upslanting palpebral fissures, hirsutism, and flexion of the elbows and wrists with deviation of the wrists and metacarpophalangeal joints. Defects in ASXL1 are a cause of myelodysplastic syndrome (MDS). A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). Belongs to the Asx family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Transcription regulation. Chromosomal Location of Human Ortholog: 20q11. Cellular Component: nuclear chromatin. Molecular Function: peroxisome proliferator activated receptor binding; protein binding; DNA binding; retinoic acid receptor binding; metal ion binding; transcription coactivator activity; transcription corepressor activity. Biological Process: negative regulation of retinoic acid receptor signaling pathway; response to retinoic acid; transcription, DNA-dependent; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation. Disease: Bohring-opitz Syndrome; Myelodysplastic Syndrome
尺寸1 :
0.1毫克
价格1 :
345美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。