抗体

小鼠单克隆抗体抗人类MYCN

MBS120139

0.1毫克

345美元

单克隆

小鼠

未共轭

986C1a

免疫印迹, dot blot

抗体

小鼠单克隆抗体抗人类MYCN

MYCN

Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian); ODED; MODED; N-myc

Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), mRNA; N-myc proto-oncogene protein; N-myc proto-oncogene protein; class E basic helix-loop-helix protein 37; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; oncogene NMYC; pp65/67; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; Class E basic helix-loop-helix protein 37; bHLHe37

MYCN

MYCN;MYCN;NMYC;ODED;MODED;N-myc;bHLHe37

MYCN_HUMAN

单克隆

IgG1

986C1a

小鼠

人类

2458

100微克/毫升(1.0毫升)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [NCBI Entrez Gene Summary]

33877057

BC002712

49,561 Da

Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

N-Myc: a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors. Protein type: Oncoprotein; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 2p24.3. Cellular Component: chromatin; nucleus. Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity. Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; negative regulation of astrocyte differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; embryonic skeletal morphogenesis; lung development; cartilage condensation. Disease: Feingold Syndrome 1; Tracheoesophageal Fistula With Or Without Esophageal Atresia

0.1毫克

345美元