小鼠单克隆抗体抗人类BCL9 | MyBioSource MBS120150 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

小鼠单克隆抗体抗人类BCL9

MBS120150

规格 :

0.1毫克

价格 :

345美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

2071C3a

反应物种 :

人类

应用 :

免疫印迹, dot blot

更多信息或购买 :

MyBioSource 产品网页

产品信息

目录号 :

MBS120150

产品类型 :

抗体

产品全称 :

小鼠单克隆抗体抗人类BCL9

产品简称 :

BCL9

产品名称同义词 :

人B细胞CLL/淋巴瘤9(BCL9);LGS;MGC131591

其他名称 :

Homo sapiens B-cell CLL/lymphoma 9 (BCL9), mRNA; B-cell CLL/lymphoma 9 protein; B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; bcl-9; protein legless homolog; B-cell CLL/lymphoma 9; Protein legless homolog

产品基因名称 :

BCL9

其他基因名称 :

BCL9;BCL9;LGS

UniProt数据库进入名 :

BCL9_HUMAN

克隆性 :

单克隆

抗体亚型 :

IgG1

克隆 :

2071C3a

宿主 :

小鼠

反应物种 :

人类

序列长度 :

6192

浓度 :

100微克/毫升(1.0毫升)

检测过的应用 :

Dot Blot (DB)

其它信息1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

其他信息2 :

Sterility: Filtered through a 0.22 um membrane.

产品描述 :

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [NCBI Entrez Gene Summary]

NCBI GI登录号 :

523425752

NCBI登录号 :

NP_004317.2

NCBI基因登录号 :

NM_004326

NCBI分子量 :

149,290 Da

NCBI信号通路 :

Disease Pathway (530764); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1127632); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (1127516); Wnt Signaling Pathway NetPath (198799); XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway (1127633); Deactivation Of The Beta-catenin Transactivating Complex Pathway (1127521)

NCBI总结 :

UniProt数据库总结 :

Bcl-9: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin s transcriptional activity. A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3 -UTR of BCL9 have been found in B-cell malignancies. Belongs to the BCL9 family. Protein type: Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: nucleoplasm; Golgi apparatus; cis-Golgi network. Molecular Function: protein binding; beta-catenin binding. Biological Process: regulation of transforming growth factor beta receptor signaling pathway; somatic stem cell maintenance; myotube differentiation involved in skeletal muscle regeneration; positive regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin

尺寸1 :

0.1毫克

价格1 :

345美元

更多信息或购买 :

MyBioSource 产品网页

公司信息