抗体

小鼠单克隆抗体抗人类CRSP2

MBS120156

0.1毫克

345美元

单克隆

小鼠

未共轭

2214C1a

免疫印迹, dot blot

抗体

小鼠单克隆抗体抗人类CRSP2

CRSP2

Homo sapiens cofactor required for Sp1 transcriptional activation,?subunit 2, 150kDa (CRSP2); CSRP; RGR1;EXLM1; MED14; CXorf4; CRSP150; DRIP150; TRAP170;MGC104513

Homo sapiens mediator complex subunit 14 (MED14), mRNA; Mediator of RNA polymerase II transcription subunit 14; mediator of RNA polymerase II transcription subunit 14; ARC150; CRSP complex subunit 2; RGR1 homolog; activator-recruited cofactor 150 kDa component; cofactor required for Sp1 transcriptional activation, subunit 2 (150kD); hRGR1; human homolog of yeast RGR1; thyroid hormone receptor-associated protein complex 170 kDa component; thyroid hormone receptor-associated protein complex component TRAP170; transcriptional co-activator CRSP150; vitamin D receptor-interacting protein complex component DRIP150; vitamin D3 receptor-interacting protein complex 150 kDa component; mediator complex subunit 14; Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150

CRSP2

MED14;MED14;CSRP;RGR1;CRSP2;EXLM1;CXorf4;CRSP150;DRIP150;TRAP170

MED14_HUMAN

单克隆

IgG1

2214C1a

小鼠

人类

6768

100微克/毫升(1.0毫升)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [NCBI Entrez Gene Summary]

154813206

NP_004220.2

NM_004229

160,607 Da

Developmental Biology Pathway (477129); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); Thyroid Hormone Signaling Pathway (946598); Transcriptional Regulation Of White Adipocyte Differentiation Pathway (205243)

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

Trap170: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 14 family. Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: Xp11.4. Cellular Component: nucleoplasm; membrane; Srb-mediator complex; nucleus. Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription coactivator activity; transcription cofactor activity; thyroid hormone receptor binding; receptor activity. Biological Process: steroid hormone receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; gene expression

0.1毫克

345美元