产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
小鼠单克隆抗体抗人类TWIST
目录 :
MBS120163
规格 :
0.1毫克
价格 :
345美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Twist2C1a
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS120163
产品类型 :
抗体
产品全称 :
小鼠单克隆抗体抗人类TWIST
产品简称 :
TWIST
产品名称同义词 :
Homo sapiens twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) (TWIST1); SCS;ACS3; BPES2; BPES3;TWIST1
其他名称 :
Homo sapiens twist family bHLH transcription factor 1 (TWIST1), mRNA; Twist-related protein 1; twist-related protein 1; B-HLH DNA binding protein; H-twist; TWIST homolog of drosophila; class A basic helix-loop-helix protein 38; twist basic helix-loop-helix transcription factor 1; twist homolog 1; twist family bHLH transcription factor 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist
产品基因名称 :
TWIST
其他基因名称 :
TWIST1;TWIST1;CRS;CSO;SCS;ACS3;CRS1;BPES2;BPES3;TWIST;bHLHa38
UniProt数据库进入名 :
TWST1_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
Twist2C1a
宿主 :
小鼠
反应物种 :
人类
序列长度 :
1669
浓度 :
100微克/毫升(1.0毫升)
检测过的应用 :
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)
其它信息1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
其他信息2 :
Sterility: Filtered through a 0.22 um membrane.
产品描述 :
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [NCBI Entrez Gene Summary]
NCBI GI登录号 :
68160957
NCBI登录号 :
NP_000465.1
NCBI基因登录号 :
NM_000474
NCBI分子量 :
20,954 Da
NCBI信号通路 :
Adipogenesis Pathway (198832); HIF-2-alpha Transcription Factor Network Pathway (137956); Neural Crest Differentiation Pathway (672460); Notch-mediated HES/HEY Network Pathway (169347); Proteoglycans In Cancer Pathway (782000); Proteoglycans In Cancer Pathway (782054)
NCBI总结 :
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
TWIST1: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Efficient DNA binding requires dimerization with another bHLH protein. Homodimer or heterodimer with E proteins such as TCF3. ID1 binds preferentially to TCF3 but does not interact efficiently with TWIST1 so ID1 levels control the amount of TCF3 available to dimerize with TWIST1 and thus determine the type of dimer formed. Subset of mesodermal cells. Protein type: Transcription regulation; Cell development/differentiation; Inhibitor; DNA-binding. Chromosomal Location of Human Ortholog: 7p21.2. Cellular Component: nucleus. Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; protein heterodimerization activity; bHLH transcription factor binding; transcription factor binding. Biological Process: embryonic forelimb morphogenesis; transcription from RNA polymerase II promoter; negative regulation of skeletal muscle development; muscle development; neuron migration; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; palate development; embryonic hindlimb morphogenesis; negative regulation of histone phosphorylation; negative regulation of histone acetylation; odontogenesis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of osteoblast differentiation; ossification; in utero embryonic development; negative regulation of transcription factor activity; outer ear morphogenesis; negative regulation of tumor necrosis factor production; embryonic cranial skeleton morphogenesis; positive regulation of tumor necrosis factor production; positive regulation of fatty acid beta-oxidation; osteoblast differentiation; positive regulation of angiogenesis; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; regulation of bone mineralization; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of phosphoinositide 3-kinase cascade. Disease: Robinow-sorauf Syndrome; Craniosynostosis 1; Saethre-chotzen Syndrome
尺寸1 :
0.1毫克
价格1 :
345美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。