小鼠单克隆抗体抗人类CRK | MyBioSource MBS120227 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

小鼠单克隆抗体抗人类CRK

MBS120227

规格 :

0.1毫克

价格 :

345美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

2210C1a

反应物种 :

人类

应用 :

免疫印迹, dot blot

更多信息或购买 :

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产品信息

目录号 :

MBS120227

产品类型 :

抗体

产品全称 :

小鼠单克隆抗体抗人类CRK

产品简称 :

CRK

产品名称同义词 :

Homo sapiens v-crk sarcoma virus CT10 oncogene homolog (avian)?(CRK), transcript variant II; CRKII

其他名称 :

Homo sapiens v-crk avian sarcoma virus CT10 oncogene homolog (CRK), transcript variant II, mRNA; Adapter molecule crk; adapter molecule crk; proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; Proto-oncogene c-Crk; p38

产品基因名称 :

CRK

其他基因名称 :

CRK;CRK;p38;CRKII

UniProt数据库进入名 :

CRK_HUMAN

克隆性 :

单克隆

抗体亚型 :

IgG1

克隆 :

2210C1a

宿主 :

小鼠

反应物种 :

人类

序列长度 :

3225

浓度 :

100微克/毫升(1.0毫升)

检测过的应用 :

Dot Blot (DB)

其它信息1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

其他信息2 :

Sterility: Filtered through a 0.22 um membrane.

产品描述 :

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [NCBI Entrez Gene Summary]

NCBI GI登录号 :

358356430

NCBI登录号 :

NP_058431.2

NCBI基因登录号 :

NM_016823

NCBI分子量 :

22,906 Da

NCBI信号通路 :

ARMS-mediated Activation Pathway (106466); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528)

NCBI总结 :

UniProt数据库总结 :

CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex. Protein type: Oncoprotein; Adaptor/scaffold; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17p13.3. Cellular Component: cytoplasm; plasma membrane; nucleus; cytosol; actin cytoskeleton. Molecular Function: protein phosphorylated amino acid binding; protein binding; SH3/SH2 adaptor activity; ephrin receptor binding; SH2 domain binding. Biological Process: regulation of transcription from RNA polymerase II promoter; platelet activation; regulation of Rac protein signal transduction; nerve growth factor receptor signaling pathway; activation of MAPKK activity; regulation of actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; insulin receptor signaling pathway; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway

尺寸1 :

0.1毫克

价格1 :

345美元

更多信息或购买 :

MyBioSource 产品网页

公司信息