抗体

小鼠单克隆抗体抗人类TCF8

MBS120270

0.1毫克

345美元

单克隆

小鼠

未共轭

416A7H10

免疫印迹, dot blot

抗体

小鼠单克隆抗体抗人类TCF8

TCF8

人锌指E拳击结合同源异形盒1(ZEB1);ZEB1;BZP;ZEB;AREB6;ZFHEP;NIL-2A;ZFHX1A;NIL-2-A

Homo sapiens zinc finger E-box binding homeobox 1 (ZEB1), transcript variant 2, mRNA; Zinc finger E-box-binding homeobox 1; zinc finger E-box-binding homeobox 1; delta-crystallin enhancer binding factor 1; negative regulator of IL2; posterior polymorphous corneal dystrophy 3; transcription factor 8 (represses interleukin 2 expression); zinc finger homeodomain enhancer-binding protein; zinc finger E-box binding homeobox 1; NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8; TCF-8

TCF8

ZEB1;ZEB1;BZP;TCF8;AREB6;FECD6;NIL2A;PPCD3;ZFHEP;ZFHX1A;DELTAEF1

ZEB1_HUMAN

单克隆

IgG1

416A7H10

小鼠

人类

5998

100微克/毫升(1.0毫升)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991).[supplied by OMIM] [NCBI Entrez Gene Summary]

291575186

NP_110378.3

NM_030751

122,084 Da

Hypertrophy Model Pathway (198828); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); TGF-beta Receptor Signaling Pathway (198774); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

TCF8: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5 -CANNTG-3 ). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Interacts (via N-terminus) with SMARCA4/BRG1. Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 10p11.2. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus. Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; double-stranded DNA binding; chromatin binding; transcription factor binding; transcription corepressor activity; transcription factor activity. Biological Process: response to nutrient levels; transcription, DNA-dependent; regulation of T cell differentiation in the thymus; semicircular canal morphogenesis; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; embryonic skeletal morphogenesis; regulation of mesenchymal cell proliferation; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; cell proliferation; regulation of transforming growth factor beta receptor signaling pathway; cartilage development; regulation of smooth muscle cell differentiation; forebrain development; positive regulation of transcription from RNA polymerase II promoter; immune response; response to activity; embryonic camera-type eye morphogenesis; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent. Disease: Corneal Dystrophy, Posterior Polymorphous, 3; Corneal Dystrophy, Fuchs Endothelial, 6

0.1毫克

345美元