抗体

小鼠单克隆抗体抗人类CLNS1A

MBS120273

0.1毫克

345美元

单克隆

小鼠

未共轭

2187C2a

免疫印迹, 免疫细胞化学

抗体

小鼠单克隆抗体抗人类CLNS1A

CLNS1A

Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A); CLCI; ICln; CLNS1B

Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A), mRNA; Methylosome subunit pICln; methylosome subunit pICln; chloride channel regulatory protein; chloride channel, nucleotide sensitive 1A; chloride conductance regulatory protein ICln; chloride ion current inducer protein; i(Cln); reticulocyte pICln; reticulocyte protein ICln; chloride channel, nucleotide-sensitive, 1A; Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln

CLNS1A

CLNS1A;CLNS1A;CLCI;ICln;CLNS1B

ICLN_HUMAN

单克隆

IgG1

2187C2a

小鼠

人类

1378

100微克/毫升(1.0毫升)

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. [UniProtKB Function]

222418789

NP_001284.1

NM_001293

26,215 Da

Gene Expression Pathway (105937); Metabolism Of Non-coding RNA Pathway (106228); RNA Transport Pathway (177876); RNA Transport Pathway (175229); SnRNP Assembly Pathway (106229)

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. [provided by RefSeq, Feb 2009]

ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family. Protein type: Channel, chloride. Chromosomal Location of Human Ortholog: 11q13.5-q14. Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; plasma membrane; nucleus; cytosol. Molecular Function: protein binding. Biological Process: spliceosomal snRNP biogenesis; chloride transport; gene expression; cell volume homeostasis

0.1毫克

345美元