产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
小鼠单克隆抗体抗人类ID2
目录 :
MBS120287
规格 :
0.1毫克
价格 :
345美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2457C5a
反应物种 :
人类
应用 :
免疫细胞化学
更多信息或购买 :
产品信息
目录号 :
MBS120287
产品类型 :
抗体
产品全称 :
小鼠单克隆抗体抗人类ID2
产品简称 :
ID2
产品名称同义词 :
Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2); GIG8; ID2A; ID2H; MGC26389
其他名称 :
Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; cell growth-inhibiting gene 8; class B basic helix-loop-helix protein 26; helix-loop-helix protein ID2; inhibitor of differentiation 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; Class B basic helix-loop-helix protein 26; bHLHb26; Inhibitor of DNA binding 2; Inhibitor of differentiation 2
产品基因名称 :
ID2
其他基因名称 :
ID2;ID2;GIG8;ID2A;ID2H;bHLHb26
UniProt数据库进入名 :
ID2_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
2457C5a
宿主 :
小鼠
反应物种 :
人类
序列长度 :
1402
浓度 :
100微克/毫升(1.0毫升)
检测过的应用 :
Dot Blot (DB), Immunocytochemistry (ICC)
其它信息1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
其他信息2 :
Sterility: Filtered through a 0.22 um membrane.
产品描述 :
The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. [NCBI Entrez Gene Summary]
NCBI GI登录号 :
33946335
NCBI登录号 :
NP_002157.2
NCBI基因登录号 :
NM_002166
NCBI分子量 :
14,917 Da
NCBI信号通路 :
HIF-1-alpha Transcription Factor Network Pathway (138045); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Id Signaling Pathway (198871); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475); Transcriptional Misregulation In Cancer Pathway (523016)
NCBI总结 :
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
UniProt数据库总结 :
ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system. Protein type: Transcription, coactivator/corepressor; DNA-binding. Chromosomal Location of Human Ortholog: 2p25. Cellular Component: nucleoplasm; microtubule cytoskeleton; centrosome; protein complex; cytoplasm; nucleus; chromatin; cytosol. Molecular Function: protein dimerization activity; protein binding. Biological Process: regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of smooth muscle cell proliferation; cell maturation; negative regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock by photoperiod; locomotor rhythm; natural killer cell differentiation; embryonic digestive tract morphogenesis; negative regulation of osteoblast differentiation; circadian regulation of gene expression; positive regulation of macrophage differentiation; oligodendrocyte development; positive regulation of astrocyte differentiation; negative regulation of B cell differentiation; Peyer s patch development; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; olfactory bulb development; negative regulation of transcription factor activity; neuron fate commitment; mammary gland epithelial cell proliferation; enucleate erythrocyte differentiation; regulation of circadian rhythm; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure
尺寸1 :
0.1毫克
价格1 :
345美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。