小鼠单克隆抗体抗人类CBLB | MyBioSource MBS120301 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

小鼠单克隆抗体抗人类CBLB

MBS120301

规格 :

0.1毫克

价格 :

345美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

246C5a

反应物种 :

人类

应用 :

免疫印迹

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产品信息

目录号 :

MBS120301

产品类型 :

抗体

产品全称 :

小鼠单克隆抗体抗人类CBLB

产品简称 :

CBLB

产品名称同义词 :

Homo sapiens Cas-Br-M (murine) ecotropic retroviral transforming sequence b; RNF56; Nbla00127

其他名称 :

Homo sapiens Cas-Br-M (murine) ecotropic retroviral transforming sequence b, mRNA; E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase CBL-B; Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cbl proto-oncogene, E3 ubiquitin protein ligase B; RING finger protein 56; SH3-binding protein CBL-B; casitas B-lineage lymphoma proto-oncogene b; signal transduction protein CBL-B; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Casitas B-lineage lymphoma proto-oncogene b; RING finger protein 56; SH3-binding protein CBL-B; Signal transduction protein CBL-B

产品基因名称 :

CBLB

其他基因名称 :

CBLB; CBLB; Cbl-b; RNF56; Nbla00127

UniProt数据库进入名 :

CBLB_HUMAN

克隆性 :

单克隆

抗体亚型 :

IgG2a

克隆 :

246C5a

宿主 :

小鼠

反应物种 :

人类

序列长度 :

3923

浓度 :

100微克/毫升(1.0毫升)

检测过的应用 :

Dot Blot (DB), Western Blot (WB)

其它信息1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

其他信息2 :

Sterility: Filtered through a 0.22 um membrane.

NCBI GI登录号 :

34192827

NCBI登录号 :

BC032851

NCBI分子量 :

86,582 Da

NCBI信号通路 :

Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); CD40/CD40L Signaling Pathway (138061); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528)

UniProt数据库总结 :

Cbl-b: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization. Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May interact with CBL. Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Ligase; Adaptor/scaffold; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; Calcium-binding. Chromosomal Location of Human Ortholog: 3q13.11. Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol. Molecular Function: signal transducer activity; protein binding; phosphotyrosine binding; zinc ion binding; ubiquitin-protein ligase activity; calcium ion binding; ligase activity. Biological Process: cell surface receptor linked signal transduction; T cell activation; positive regulation of protein catabolic process; negative regulation of T cell receptor signaling pathway; protein ubiquitination; negative regulation of alpha-beta T cell proliferation; immune response; NLS-bearing substrate import into nucleus; signal transduction; positive regulation of T cell anergy

尺寸1 :

0.1毫克

价格1 :

345美元

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公司信息