产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
小鼠单克隆抗体抗人类HAND2
目录 :
MBS120421
规格 :
0.1毫克
价格 :
345美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HAND2C1a
反应物种 :
人类
应用 :
免疫印迹, dot blot
更多信息或购买 :
产品信息
目录号 :
MBS120421
产品类型 :
抗体
产品全称 :
小鼠单克隆抗体抗人类HAND2
产品简称 :
HAND2
产品名称同义词 :
Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.; Hed; dHand; DHAND2; Thing2; FLJ16260; MGC125303; MGC125304
其他名称 :
Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA; heart- and neural crest derivatives-expressed protein 2; basic helix-loop-helix transcription factor HAND2; class A basic helix-loop-helix protein 26; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; heart and neural crest derivatives expressed 2
产品基因名称 :
HAND2
其他基因名称 :
HAND2; HAND2; Hed; dHand; DHAND2; Thing2; bHLHa26
UniProt数据库进入名 :
HAND2_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
HAND2C1a
宿主 :
小鼠
反应物种 :
人类
序列长度 :
2368
浓度 :
100微克/毫升(1.0毫升)
检测过的应用 :
Dot Blot (DB)
其它信息1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
其他信息2 :
Sterility: Filtered through a 0.22 um membrane.
产品描述 :
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.[NCBI Entrez Gene Summary]
NCBI GI登录号 :
88999597
NCBI登录号 :
NP_068808.1
NCBI基因登录号 :
NM_021973
NCBI分子量 :
20,269 Da
NCBI信号通路 :
Heart Development Pathway (198802)
NCBI总结 :
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
HAND2: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5 -CANNTG-3 . Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 4q33. Cellular Component: transcription factor complex; protein complex; nuclear chromatin. Molecular Function: protein binding; protein homodimerization activity; transcription activator binding; AT DNA binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding. Biological Process: heart morphogenesis; adult heart development; tongue development; thymus development; transcription, DNA-dependent; neural crest cell development; in utero embryonic development; apoptosis; negative regulation of transcription factor activity; heart development; positive regulation of transcription, DNA-dependent; mesenchymal cell proliferation; palate development; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; peripheral nervous system neuron development; sympathetic nervous system development; regulation of transcription, DNA-dependent; suckling behavior; negative regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; heart looping; angiogenesis; embryonic digit morphogenesis
尺寸1 :
0.1毫克
价格1 :
345美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。