蛋白

重组人类Toll样受体2

MBS1213928

0.05毫克(大肠杆菌)

190美元

重组蛋白

重组人类Toll样受体2

Toll样受体2

Toll/interleukin-1 receptor-like protein 4; CD282

toll-like receptor 2; Toll-like receptor 2; toll-like receptor 2; toll like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD_antigen: CD282

Toll样受体2

Toll样受体2;Toll样受体2;TIL4;CD282;TIL4

TLR2_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

19-588

784

KEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSL
DLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF
SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP
YKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLT
FLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILL
LEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIK
KFTFRNVKITDESLFQVMKLL

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

免疫学

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4 evidence for a multi-gene receptor family in humans.Chaudhary P.M., Ferguson C., Nguyen V., Nguyen O., Massa H.F., Eby M., Jasmin A., Trask B.J., Hood L., Nelson P.S.Blood 91:4020-4027(1998) A family of human receptors structurally related to Drosophila Toll.Rock F.L., Hardiman G., Timans J.C., Kastelein R.A., Bazan J.F.Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.Yang R.-B., Mark M.R., Gray A.M., Huang A., Xie M.-H., Zhang M., Goddard A.D., Wood W.I., Gurney A.L., Godowski P.J.Nature 395:284-288(1998) Natural selection in the TLR-related genes in the course of primate evolution.Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.Immunogenetics 60:727-735(2008) The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.Georgel P., Macquin C., Bahram S.PLoS ONE 4:E7803-E7803(2009)

19718734

NP_003255.2

NM_003264.4

O60603

80.4kD

Activated TLR4 Signalling Pathway (1269236); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Beta Defensins Pathway (1269267); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Defensins Pathway (1269265); Disease Pathway (1268854); Diseases Associated With The TLR Signaling Cascade Pathway (1269157); Diseases Of Immune System Pathway (1269156)

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

0.05毫克(大肠杆菌)

190美元

0.2毫克(大肠杆菌)

460

0.5毫克(大肠杆菌)

750

1毫克(大肠杆菌)

1180

0.05毫克(杆状病毒)

1370