产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
磷酸化成纤维细胞生长因子受体1-Y654多克隆抗体
目录 :
MBS125405
规格 :
0.05毫升
价格 :
265美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS125405
产品类型 :
抗体
产品全称 :
磷酸化成纤维细胞生长因子受体1-Y654多克隆抗体
产品简称 :
成纤维细胞生长因子受体1-Y654
产品名称同义词 :
磷酸化FGFR1:N/A
其他名称 :
Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 1; fibroblast growth factor receptor 1; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD_antigen: CD331
产品基因名称 :
FGFR1
其他基因名称 :
FGFR1;FGFR1;CEK;FLG;HH2;OGD;FLT2;KAL2;BFGFR;CD331;FGFBR;FLT-2;HBGFR;N-SAM;FGFR-1;HRTFDS;bFGF-R-1;BFGFR;CEK;FGFBR;FLG;FLT2;HBGFR;FGFR-1;BFGFR;bFGF-R-1;FLT-2
UniProt数据库进入名 :
FGFR1_HUMAN
抗体亚型 :
IgG
宿主 :
反应物种 :
小鼠
序列长度 :
822
纯度 :
亲和纯化
检测过的应用 :
免疫印迹(免疫印迹)
其它信息1 :
Species: Human. Route: Synthetic Peptide
产品种类 :
磷酸化
NCBI GI登录号 :
120046
NCBI登录号 :
P11362.3
UniProt数据库登录号 :
P11362
NCBI分子量 :
822
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Axon Guidance Pathway (105688); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Developmental Biology Pathway (477129)
NCBI总结 :
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described. Protein type: Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; FGFR family. Chromosomal Location of Human Ortholog: 8p11.23-p11.22. Cellular Component: integral to plasma membrane; cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane; extracellular region; cytosol; nucleus; receptor complex. Molecular Function: heparin binding; identical protein binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding. Biological Process: paraxial mesoderm development; axon guidance; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; cell maturation; neuron migration; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; induction of an organ; regulation of cell differentiation; positive regulation of mesenchymal cell proliferation; midbrain development; positive regulation of cell proliferation; chondrocyte differentiation; angiogenesis; skeletal development; positive regulation of cardiac muscle cell proliferation; embryonic limb morphogenesis; epidermal growth factor receptor signaling pathway; cell migration; inner ear morphogenesis; chordate embryonic development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; in utero embryonic development; outer ear morphogenesis; MAPKKK cascade; positive regulation of cell cycle; neuroblast division in the ventricular zone; positive regulation of phosphoinositide 3-kinase cascade; mesenchymal cell differentiation; skeletal morphogenesis; insulin receptor signaling pathway; auditory receptor cell development; innate immune response; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification. Disease: Pfeiffer Syndrome; Hypogonadotropic Hypogonadism 2 With Or Without Anosmia; Jackson-weiss Syndrome; Trigonocephaly 1; Osteoglophonic Dysplasia
尺寸1 :
0.05毫升
价格1 :
265美元
尺寸2 :
0.1毫升
价格2 :
380
size3 :
0.2毫升
价格3 :
555
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。