产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
cPLA2多克隆抗体
目录 :
MBS125633
规格 :
0.1毫克
价格 :
305美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS125633
产品类型 :
抗体
产品全称 :
cPLA2多克隆抗体
产品简称 :
cPLA2
产品名称同义词 :
Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA; Lysophospholipase; PLA2G4; CPLA2; PLA2G4A
其他名称 :
Cytosolic phospholipase A2; Cytosolic phospholipase A2; cytosolic phospholipase A2; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; phospholipase A2, group IVA (cytosolic, calcium-dependent); Phospholipase A2 group IVAIncluding the following 2 domains:Phospholipase A2 (EC:3.1.1.4)Alternative name(s):Phosphatidylcholine 2-acylhydrolase
产品基因名称 :
PLA2G4A
其他基因名称 :
PLA2G4A;PLA2G4A;PLA2G4;cPLA2甲;CPLA2;PLA2G4;cPLA2
UniProt数据库进入名 :
PA24A_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类
序列长度 :
749
纯度 :
亲和纯化
浓度 :
1毫克/毫升
储存稳定性 :
Store at 4 degree C (regular) or -20 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 流式细胞仪(FC/流式细胞仪)
应用笔记 :
WB: 1:200 - 1:500。 IHC: 1:50 - 1:100。 IF: 1:20 - 1:50。 FC: 1:20 - 1:50
其它信息1 :
Species: Human. Route: Synthetic Peptide
其他信息2 :
Immunogen: A synthetic peptide of human cPLA2. Calculated Molecular Weight: 85kDa
产品种类 :
多克隆
产品描述 :
Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and release arachidonic acid (1). cPLA2 has been implicated in diverse cellular responses such as mitogenesis, differentiation, inflammation and cytotoxicity (1). Calcium binding to the amino-terminal CalB domain of cPLA2 promotes the translocation of cPLA2 from cytosol to membrane, where cPLA2 cleaves arachidonic acid from natural membrane (2). Phosphorylation of cPLA2 by MAPK (p42/44 and p38) at Ser505 (3,4) and Ser727 (5) stimulates its catalytic activity.
NCBI GI登录号 :
317373312
NCBI登录号 :
P47712.2
UniProt数据库登录号 :
P47712
NCBI分子量 :
749
NCBI信号通路 :
ADP Signalling Through P2Y Purinoceptor 1 Pathway 161061!!AGE/RAGE Pathway 698754!!Acyl Chain Remodeling Of CL Pathway 645330!!Acyl Chain Remodelling Of PC Pathway 645321!!Acyl Chain Remodelling Of PE Pathway 645317!!Acyl Chain Remodelling Of PG Pathway 645328!!Acyl Chain Remodelling Of PI Pathway 645326!!Acyl Chain Remodelling Of PS Pathway 645324!!Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 685553
NCBI总结 :
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
规格 :
0.1毫克
价格 :
305美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。