产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
SNCA多克隆抗体
目录 :
MBS125846
规格 :
0.05毫克
价格 :
285美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
MyBioSource 产品网页
产品信息
目录号 :
MBS125846
产品类型 :
抗体
产品全称 :
SNCA多克隆抗体
产品简称 :
SNCA
产品名称同义词 :
alpha-Synuclein: a-Synuclein; TLR7-like
其他名称 :
Alpha-synuclein; Alpha-synuclein; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
产品基因名称 :
SNCA
其他基因名称 :
SNCA;SNCA;PD1;NACP;PARK1;PARK4;NACP;PARK1;NACP
UniProt数据库进入名 :
SYUA_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
140
纯度 :
亲和纯化
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
WB: 1:200 - 1:2000。 IHC: 1:50 - 1:200
其它信息1 :
Species: Human. Route: Recombinant Protein
其他信息2 :
Immunogen: Fusion protein of human SNCA. Calculated Molecular Weight: 14kDa
产品种类 :
多克隆
产品描述 :
SNCA, also named as NACP, PARK1 and Alpha-synuclein, belongs to the synuclein family. It may be involved in the regulation of dopamine release and transport. SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. The deposition of aggregated SNCa is the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV).(PMID:21056999) This antibody can recognize all the isoforms of SNCA.
NCBI GI登录号 :
586067
NCBI登录号 :
P37840.1
UniProt数据库登录号 :
P37840
NCBI分子量 :
140
NCBI信号通路 :
Alpha-synuclein Signaling Pathway 137913!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Amyloids Pathway 366238!!Disease Pathway 530764!!EGFR1 Signaling Pathway 198782!!Parkin-Ubiquitin Proteasomal System Pathway 700638!!Parkinson's Disease Pathway 83098!!Parkinsons Disease Pathway 705377
NCBI总结 :
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
规格 :
0.05毫克
价格 :
285美元
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。