抗体

Rabbit anti-human Endothelial protein C receptor polyclonal Antibody, Biotin conjugated

MBS1265009

0.05毫克

160美元

多克隆

兔

生物素

抗体

Rabbit anti-human Endothelial protein C receptor polyclonal Antibody, Biotin conjugated

Endothelial protein C receptor

激活的蛋白C受体;内皮细胞 蛋白C受体;CD_antigen=CD201;PROCR;EPCR

endothelial protein C receptor; Endothelial protein C receptor; endothelial protein C receptor; protein C receptor; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD_antigen: CD201

PROCR;PROCR;CCCA;EPCR;CCD41;EPCR;APC受体

EPCR_HUMAN

多克隆

IgG

兔

人类

238

Caprylic Acid Ammonium Sulfate Precipitation Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)。 尚未在其他应用中测试

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Biotin

Immunogen: Recombinant human Endothelial protein C receptor protein

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

34335272

NP_006395.2

NM_006404.4

Q9UNN8

26,671 Da

Cell Surface Interactions At The Vascular Wall Pathway (1269373); Common Pathway Of Fibrin Clot Formation (1269371); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368); Hemostasis Pathway (1269340)

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: cell surface; centrosome; extracellular region; focal adhesion; integral to plasma membrane; plasma membrane. Molecular Function: protein binding; receptor activity. Biological Process: blood coagulation; immune response; leukocyte migration; negative regulation of coagulation

0.05毫克

160美元

0.1毫克

235