蛋白

重组人类孕酮受体

MBS1265262

0.05毫克(大肠杆菌)

190美元

重组蛋白

重组人类孕酮受体

孕激素受体

Nuclear receptor subfamily 3 group C member 3

progesterone receptor isoform B; Progesterone receptor; progesterone receptor; progesterone receptor; Nuclear receptor subfamily 3 group C member 3

PGR

NR3C3

PGR;PGR;PR;NR3C3;NR3C3;PR

PRGR_HUMAN

大肠杆菌

4-232

933

LKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTS
DTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLS
DVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQR
VLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLP
ASESPHWSGAPVKPSPQAAAVEVEEEDGSESEES

Greater than 90% as determined by SDS-PAGE.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

转录

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.Kastner P., Krust A., Turcotte B., Stropp U., Tora L., Gronemeyer H., Chambon P.EMBO J. 9:1603-1614(1990) Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA.Misrahi M., Atger M., D'Auriol L., Loosfelt H., Meriel C., Fridlansky F., Guiochon-Mantel A., Galibert F., Milgrom E.Biochem. Biophys. Res. Commun. 143:740-748(1987) Kieback D.G., Agoulnik I.U., Tong X.-W.Progesterone Receptor, alternative splicing variant, mRNA.Hisatomi H., Wakita K., Kohno N., Nagao K., Hirata H., Hikiji K. The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor.Chen C., Opazo J.C., Erez O., Uddin M., Santolaya-Forgas J., Goodman M., Grossman L.I., Romero R., Wildman D.E.Mol. Phylogenet. Evol. 47:637-649(2008) Cloning and expression of a novel, truncated, progesterone receptor.Saner K.J., Welter B.H., Zhang F., Hansen E., Dupont B., Wei Y., Price T.M.Mol. Cell. Endocrinol. 200:155-163(2003) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) NIEHS SNPs programHuman chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006)

110611914

NP_000917.3

NM_000926.4

P06401

50.7kD

Cellular Roles Of Anthrax Toxin Pathway (138076); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Nuclear Receptor Transcription Pathway (1269652); Nuclear Receptors Pathway (198848); Nuclear Signaling By ERBB4 Pathway (1269499); Oocyte Meiosis Pathway (126909); Oocyte Meiosis Pathway (126872); Ovarian Infertility Genes Pathway (198801); Progesterone-mediated Oocyte Maturation Pathway (119304)

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

PR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 11q22-q23. Cellular Component: mitochondrial outer membrane; nucleoplasm. Molecular Function: ATPase binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; protein binding; receptor binding; steroid binding; steroid hormone receptor activity; zinc ion binding. Biological Process: alveolus development; cell-cell signaling; epithelial cell maturation; gene expression; ovulation from ovarian follicle; positive regulation of transcription from RNA polymerase II promoter; progesterone receptor signaling pathway; regulation of epithelial cell proliferation; signal transduction; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter. Disease: Progesterone Resistance

0.05毫克(大肠杆菌)

190美元

0.2毫克(大肠杆菌)

460

0.5毫克(大肠杆菌)

750

1毫克(大肠杆菌)

1180