产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
TYK2多克隆抗体
目录 :
MBS126617
规格 :
0.05毫升
价格 :
230美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
MyBioSource 产品网页
产品信息
目录号 :
MBS126617
产品类型 :
抗体
产品全称 :
TYK2多克隆抗体
产品简称 :
TYK2
产品名称同义词 :
JTK1
其他名称 :
Non-receptor tyrosine-protein kinase TYK2; Non-receptor tyrosine-protein kinase TYK2; non-receptor tyrosine-protein kinase TYK2; tyrosine kinase 2
产品基因名称 :
TYK2
其他基因名称 :
TYK2;TYK2;JTK1;IMD35
UniProt数据库进入名 :
TYK2_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
1187
纯度 :
亲和纯化
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
WB: 1:500 - 1:2000。 IHC: 1:50 - 1:200
其它信息1 :
Species: Human. Immunogen: Recombinant Protein
其他信息2 :
Immunogen: Recombinant protein of human TYK2. Calculated Molecular Weight: 134kDa
产品种类 :
多克隆
产品描述 :
Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-alpha and beta (1-3). Following ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055 (4). Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-beta signaling cascade (5).
NCBI GI登录号 :
56405328
NCBI登录号 :
P29597.3
UniProt数据库登录号 :
P29597
NCBI分子量 :
1187
NCBI信号通路 :
ARMS-mediated Activation Pathway (106466); Activated TLR4 Signalling Pathway (106400); Axon Guidance Pathway (105688); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Developmental Biology Pathway (477129); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Of Activated FGFR Pathway (160957)
NCBI总结 :
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. Protein type: Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding. Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation. Disease: Immunodeficiency 35
尺寸1 :
0.05毫升
价格1 :
230美元
尺寸2 :
0.1毫升
价格2 :
305
size3 :
0.2毫升
价格3 :
460
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。