产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
HNF4A多克隆抗体
目录 :
MBS126772
规格 :
0.05毫升
价格 :
200美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS126772 图像 1
Western blot analysis of extracts of various cell lines, using HNF4A antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
图像 2 :
MyBioSource MBS126772 图像 2
Immunohistochemistry of paraffin-embedded rat pancreas using HNF4A Antibody at dilution of 1:100 (40x lens).
图像 3 :
MyBioSource MBS126772 图像 3
Immunohistochemistry of paraffin-embedded mouse liver using HNF4A Antibody at dilution of 1:100 (40x lens).
产品信息
目录号 :
MBS126772
产品类型 :
抗体
产品全称 :
HNF4A多克隆抗体
产品简称 :
[HNF4A]
产品名称同义词 :
[FRTS4;HNF4A;HNF4;HNF4a7;HNF4a8;HNF4a9;HNF4alpha;MODY;MODY1;NR2A1;NR2A21;TCF;TCF14]
其他名称 :
[Hepatocyte nuclear factor 4-alpha; Hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4-alpha; TCF-14; HNF4alpha10/11/12; transcription factor 14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1; hepatocyte nuclear factor 4, alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4]
产品基因名称 :
[HNF4A]
其他基因名称 :
[HNF4A;HNF4A;TCF;HNF4;MODY;FRTS4;MODY1;NR2A1;TCF14;HNF4a7;HNF4a8;HNF4a9;NR2A21;HNF4alpha;HNF4;NR2A1;TCF14;HNF-4-alpha;TCF-14]
UniProt数据库进入名 :
HNF4A_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
474
纯度 :
亲和纯化
储存稳定性 :
存放在-20°C。 避免反复冷冻/解冻
检测过的应用 :
免疫印迹, 免疫组化
应用笔记 :
WB: 1:500 - 1:2000。 IHC: 1:50 - 1:200
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫组化(免疫组化)
image4头 :
免疫组化(免疫组化)
image4描述 :
Immunohistochemistry of paraffin-embedded rat liver using HNF4A Antibody at dilution of 1:100 (40x lens).
image5头 :
免疫组化(免疫组化)
image5描述 :
Immunohistochemistry of paraffin-embedded rat pancreas using HNF4A Antibody at dilution of 1:100 (40x lens).
其它信息1 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
其他信息2 :
Immunogen: A synthetic peptide of human HNF4A. Calculated MW: 43-56kDa. Observed MW: 53 kDa
产品种类 :
多克隆
产品描述 :
Hepatocyte nuclear factor 4alpha (HNF4alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4alpha, in association with PGC-1alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2,3). Conditional knockout of the HNF4alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4alpha have been linked to maturity-onset diabetes of the young (MODY) (5).
NCBI GI登录号 :
148886624
NCBI登录号 :
P41235.3
UniProt数据库登录号 :
P41235
NCBI信号通路 :
AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Developmental Biology Pathway (477129); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); HIF-1-alpha Transcription Factor Network Pathway (138045); Integrated Pancreatic Cancer Pathway (711360); Maturity Onset Diabetes Of The Young Pathway (83096)
NCBI总结 :
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
UniProt数据库总结 :
HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described. Protein type: Nuclear receptor; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 20q13.12. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; DNA binding; zinc ion binding; steroid hormone receptor activity; transcription factor activity; fatty acid binding; receptor binding. Biological Process: transcription initiation from RNA polymerase II promoter; regulation of lipid metabolic process; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; lipid homeostasis; glucose homeostasis; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; xenobiotic metabolic process; regulation of gastrulation; response to glucose stimulus; ornithine metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; lipid metabolic process; negative regulation of cell growth; blood coagulation; regulation of insulin secretion; sex differentiation; phospholipid homeostasis. Disease: Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1; Diabetes Mellitus, Noninsulin-dependent
尺寸1 :
0.05毫升
价格1 :
200美元
尺寸2 :
0.1毫升
价格2 :
275
size3 :
0.2毫升
价格3 :
430
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。