抗体

NOX4多克隆抗体

MBS127001

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 免疫细胞化学

抗体

NOX4多克隆抗体

[NOX4]

[KOX;KOX-1;RENOX]

[NADPH oxidase 4; NADPH oxidase 4; NADPH oxidase 4; kidney oxidase-1; renal NAD(P)H-oxidase; kidney superoxide-producing NADPH oxidase; NADPH oxidase 4; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase]

[NOX4]

[NOX4;NOX4;KOX;KOX-1;RENOX;RENOX;KOX-1]

NOX4_HUMAN

多克隆

IgG

兔

人类, 小鼠

578

亲和纯化

存放在-20°C。 避免反复冷冻/解冻

免疫印迹(免疫印迹), 免疫荧光(IF)

WB: 1:500 - 1:2000。 IF 1:10-1:100

免疫印迹(免疫印迹)

免疫荧光(IF)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 444-578 of human NOX4 (NP_058627.1). Calculated MW: 6kDa/25-31kDa/58-66kDa. Observed MW: 67 kDa

多克隆

NOX4 (NADPH oxidase 4) is a phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes with resultant antimicrobial activity and it has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.NOX4 has 7 isforms and the molecular weight are 7KDa,26-32KDa,58-67KDa,75-80KDa(PMID:11728818).This antibody is specific to NOX4.

212276447

Q9NPH5.2

Q9NPH5

Oxidative Stress Pathway (198916); Signaling Events Mediated By PTP1B Pathway (138017); Spinal Cord Injury Pathway (739007)

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; EC 1.6.3.-; Membrane protein, multi-pass; Cell cycle regulation; Nucleolus; Oxidoreductase. Chromosomal Location of Human Ortholog: 11q14.2-q21. Cellular Component: endoplasmic reticulum membrane; focal adhesion; mitochondrion; perinuclear region of cytoplasm; apical plasma membrane; nucleolus; integral to membrane; stress fiber; NADPH oxidase complex. Molecular Function: oxygen sensor activity; electron carrier activity; FAD binding; NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; nucleotide binding; heme binding. Biological Process: positive regulation of apoptosis; cell morphogenesis; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; response to hypoxia; inflammatory response; superoxide release; bone resorption

0.05毫升

200美元

0.1毫升

275

0.2毫升

430