抗体

ID2多克隆抗体

MBS127605

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

ID2多克隆抗体

[ID2]

[ID2; GIG8; ID2A; ID2H; bHLHb26; DNA-binding protein inhibitor ID-2]

[DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID-2; helix-loop-helix protein ID2; cell growth-inhibiting gene 8; inhibitor of differentiation 2; DNA-binding protein inhibitor ID2; class B basic helix-loop-helix protein 26; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; Class B basic helix-loop-helix protein 26; bHLHb26; Inhibitor of DNA binding 2; Inhibitor of differentiation 2]

[ID2]

[ID2;ID2;GIG8;ID2A;ID2H;bHLHb26;BHLHB26;bHLHb26]

ID2_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

134

亲和纯化

存放在-20°C。 避免反复冷冻/解冻

免疫印迹(免疫印迹)

WB: 1:500 - 1:2000

免疫印迹(免疫印迹)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 75-134 of human ID2 (NP_002157.2) . Calculated MW: 14 kDa . Observed MW: 15 kDa . Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

多克隆

Inhibitor of DNA-binding-2 (Id2) is a member of the Id proteins which belong to the helix-loop-helix (HLH) protein family. The Id protein functions by binding to specific transcription factors and preventing their dimerization and DNA binding (1-3). Id2 interacts with a wide variety of transcription factors including E proteins (5), TCS (4), Pax (6) and the tumor suppressor Rb (1). Id2 has been shown to be important in regulating cellular differentiation, proliferation, development and tumorgenesis (7-9). In tumor cells, increased levels of Id2 functionally inactivate Rb, leading to cellular transformation and cancer (10,11). Id2 is therefore a promising therapeutic target for treatment of cancer (12).

729806

Q02363.1

Q02363

HIF-1-alpha Transcription Factor Network Pathway (138045); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Id Signaling Pathway (198871); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475); Transcriptional Misregulation In Cancer Pathway (523016)

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system. Protein type: DNA-binding; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 2p25. Cellular Component: microtubule cytoskeleton; nucleoplasm; centrosome; protein complex; cytoplasm; nucleus; chromatin; cytosol. Molecular Function: protein dimerization activity; protein binding. Biological Process: regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of smooth muscle cell proliferation; cell maturation; negative regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock by photoperiod; locomotor rhythm; embryonic digestive tract morphogenesis; natural killer cell differentiation; negative regulation of osteoblast differentiation; circadian regulation of gene expression; positive regulation of macrophage differentiation; oligodendrocyte development; positive regulation of astrocyte differentiation; Peyer s patch development; negative regulation of B cell differentiation; transcription, DNA-dependent; negative regulation of transcription factor activity; positive regulation of erythrocyte differentiation; olfactory bulb development; neuron fate commitment; mammary gland epithelial cell proliferation; enucleate erythrocyte differentiation; regulation of circadian rhythm; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure

0.05毫升

200美元

0.1毫升

275

0.2毫升

430