产品简要
公司名称 :
MyBioSource
产品类型 :
cDNA
产品名称 :
肿瘤坏死因子cDNA克隆
目录 :
MBS1277357
规格 :
0.01毫克质粒+0
价格 :
165美元
更多信息或购买 :
产品信息
目录号 :
MBS1277357
产品类型 :
cDNA克隆
产品全称 :
肿瘤坏死因子cDNA克隆
产品简称 :
肿瘤坏死因子
其他名称 :
Homo sapiens tumor necrosis factor (TNF superfamily, member 2), mRNA; Tumor necrosis factor; tumor necrosis factor; tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a
产品基因名称 :
肿瘤坏死因子
其他基因名称 :
肿瘤坏死因子;肿瘤坏死因子;DIF;TNFA;TNFSF2;TNLG1F;肿瘤坏死因子甲;TNFA;TNFSF2;肿瘤坏死因子-a;NTF;ICD1;ICD2
UniProt数据库进入名 :
TNFA_HUMAN
序列长度 :
1676
序列 :
atgagcactgaaagcatgatccgggacgtggagctggcc
gaggaggcgctccccaagaagacaggggggccccagggc
tccaggcggtgcttgttcctcagcctcttctccttcctg
atcgtggcaggcgccaccacgctcttctgcctgctgcac
tttggagtgatcggcccccagagggaagagttccccagg
gacctctctctaatcagccctctggcccaggcagtcaga
tcatcttctcgaaccccgagtgacaagcctgtagcccat
gttgtagcaaaccctcaagctgaggggcagctccagtgg
ctgaaccgccgggccaatgccctcctggccaatggcgtg
gagctgagagataaccagctggtggtgccatcagagggc
ctgtacctcatctactcccaggtcctcttcaagggccaa
ggctgcccctccacccatgtgctcctcacccacaccatc
agccgcatcgccgtctcctaccagaccaaggtcaacctc
ctctctgccatcaagagcccctgccagagggagacccca
gagggggctgaggccaagccctggtatgagcccatctat
ctgggaggggtcttccagctggagaagggtgaccgactc
agcgctgagatcaatcggcccgactatctcgactttgcc
gagtctgggcaggtctactttgggatcattgccctgtga
gaggaggcgctccccaagaagacaggggggccccagggc
tccaggcggtgcttgttcctcagcctcttctccttcctg
atcgtggcaggcgccaccacgctcttctgcctgctgcac
tttggagtgatcggcccccagagggaagagttccccagg
gacctctctctaatcagccctctggcccaggcagtcaga
tcatcttctcgaaccccgagtgacaagcctgtagcccat
gttgtagcaaaccctcaagctgaggggcagctccagtgg
ctgaaccgccgggccaatgccctcctggccaatggcgtg
gagctgagagataaccagctggtggtgccatcagagggc
ctgtacctcatctactcccaggtcctcttcaagggccaa
ggctgcccctccacccatgtgctcctcacccacaccatc
agccgcatcgccgtctcctaccagaccaaggtcaacctc
ctctctgccatcaagagcccctgccagagggagacccca
gagggggctgaggccaagccctggtatgagcccatctat
ctgggaggggtcttccagctggagaagggtgaccgactc
agcgctgagatcaatcggcccgactatctcgactttgcc
gagtctgggcaggtctactttgggatcattgccctgtga
其它信息1 :
Vector: Please Inquire
NCBI GI登录号 :
20381341
NCBI登录号 :
BC028148
NCBI分子量 :
25,644 Da
NCBI信号通路 :
Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); AhR Pathway (755436); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509)
NCBI总结 :
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
TNF-a: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Homotrimer. Interacts with SPPL2B. Belongs to the tumor necrosis factor family. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cytokine; Apoptosis. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cell surface; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; lipid raft; phagocytic cup; plasma membrane; recycling endosome. Molecular Function: cytokine activity; identical protein binding; protease binding; protein binding; tumor necrosis factor receptor binding. Biological Process: activation of MAPK activity; activation of MAPKKK activity; activation of NF-kappaB transcription factor; caspase activation; chronic inflammatory response to antigenic stimulus; cortical actin cytoskeleton organization and biogenesis; embryonic gut development; I-kappaB kinase/NF-kappaB cascade; induction of apoptosis via death domain receptors; inflammatory response; leukocyte tethering or rolling; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; negative regulation of cytokine secretion during immune response; negative regulation of interleukin-6 production; negative regulation of lipid catabolic process; negative regulation of protein complex disassembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of viral genome replication; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of cell adhesion; positive regulation of chemokine biosynthetic process; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of cytokine secretion; positive regulation of fever; positive regulation of heterotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of JNK activity; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of NF-kappaB import into nucleus; positive regulation of NFAT protein import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phagocytosis; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of protein complex assembly; positive regulation of protein complex disassembly; positive regulation of protein kinase activity; positive regulation of protein transport; positive regulation of smooth muscle cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein import into nucleus, translocation; protein kinase B signaling cascade; receptor biosynthetic process; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of insulin secretion; response to glucocorticoid stimulus; response to salt stress; response to virus; sequestering of triacylglycerol; tumor necrosis factor-mediated signaling pathway. Disease: Asthma, Susceptibility To; Malaria, Susceptibility To; Migraine With Or Without Aura, Susceptibility To, 1
尺寸1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
价格1 :
165美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。