抗体

磷酸化胰岛素受体底物1多克隆抗体

MBS128544

0.05毫升

235美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

磷酸化胰岛素受体底物1多克隆抗体

[胰岛素受体底物1-S307]

[磷酸化IRS1:HIRS-1]

[Insulin receptor substrate 1; Insulin receptor substrate 1; insulin receptor substrate 1; IRS-1; insulin receptor substrate 1]

[胰岛素受体底物1]

[胰岛素受体底物1;胰岛素受体底物1;HIRS-1;IRS-1]

IRS1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

1242

亲和纯化

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

免疫组化(免疫组化)

IHC: 1:50 - 1:100

免疫组化(免疫组化)

Species: Human. Route: Synthetic Peptide. Category: Primary antibody

Immunogen: A phospho specific peptide corresponding to residues surrounding S307 of human IRS1. Calculated Molecular Weight: 180kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.

磷酸化

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

547738

P35568.1

P35568

1242

AGE/RAGE Pathway (698754); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adaptive Immune System Pathway (366160); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Alpha6-Beta4 Integrin Signaling Pathway (198807)

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2q36. Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; nucleus; cytosol. Molecular Function: insulin-like growth factor receptor binding; signal transducer activity; protein binding; protein kinase C binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding. Biological Process: response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; signal transduction; glucose homeostasis; negative regulation of insulin secretion; response to insulin stimulus; positive regulation of glucose import; mammary gland development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; protein kinase B signaling cascade; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of phosphoinositide 3-kinase activity; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; regulation of gene expression; insulin receptor signaling pathway; innate immune response; positive regulation of insulin receptor signaling pathway; lipid catabolic process; positive regulation of cell migration. Disease: Diabetes Mellitus, Noninsulin-dependent

0.05毫升

235美元

0.1毫升

350

0.2毫升

525