产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Phospho-Bad-S136 Polyclonal Antibody
目录 :
MBS128547
规格 :
0.05毫升
价格 :
235美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS128547 图像 1
Western blot analysis of extracts from HT29 cells using Phospho-Bad-S136 antibody. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA.
图像 2 :
MyBioSource MBS128547 图像 2
Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-Bad-S136 antibody.
产品信息
目录号 :
MBS128547
产品类型 :
抗体
产品全称 :
Phospho-Bad-S136 Polyclonal Antibody
产品简称 :
[Bad-S136]
产品名称同义词 :
[Phospho-Bad-S136: BBC2; BCL2L8]
其他名称 :
[Bcl2-associated agonist of cell death; Bcl2-associated agonist of cell death; bcl2-associated agonist of cell death; bcl-2-binding component 6; bcl2 antagonist of cell death; bcl-xL/Bcl-2-associated death promoter; BCL2-associated agonist of cell death; Bcl-2-binding component 6; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death]
产品基因名称 :
[Bad]
其他基因名称 :
[Bad; Bad; Bbc2; AI325008; Bbc6; BAD]
UniProt数据库进入名 :
BAD_MOUSE
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠
序列长度 :
204
纯度 :
亲和纯化
形式 :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
储存稳定性 :
存放在-20°C。 避免反复冷冻/解冻
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
WB: 1:500 - 1:2000。 IHC: 1:50 - 1:100
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
其它信息1 :
Calculated MW: 18kDa. Observed MW: 18kDa . Immunogen: A phospho specific peptide corresponding to residues surrounding S136 of human Bad.
产品种类 :
磷酸化
产品描述 :
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
NCBI GI登录号 :
2493288
NCBI登录号 :
Q61337.1
UniProt数据库登录号 :
Q92934
NCBI信号通路 :
AKT Phosphorylates Targets In The Cytosol Pathway (1110363); Activation Of BAD And Translocation To Mitochondria Pathway (1111505); Activation Of BH3-only Proteins Pathway (1111504); Acute Myeloid Leukemia Pathway (83310); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (1110669); Alpha6-Beta4 Integrin Signaling Pathway (198373); Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Amyotrophic Lateral Sclerosis (ALS) Pathway (83296)
UniProt数据库总结 :
BAD: a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL. Protein type: Apoptosis. Cellular Component: mitochondrial outer membrane; mitochondrion; membrane; cytoplasm; intracellular; cytosol. Molecular Function: protein kinase B binding; protein binding; protein heterodimerization activity; phospholipid binding; caspase activator activity; protein kinase binding; lipid binding; protein phosphatase binding; protein phosphatase 2B binding. Biological Process: positive regulation of proteolysis; apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; regulation of caspase activity; cellular process regulating host cell cycle in response to virus; glucose homeostasis; positive regulation of apoptosis by virus; regulation of apoptosis; pore complex biogenesis; positive regulation of glucokinase activity; caspase activation; release of cytochrome c from mitochondria; cytokine and chemokine mediated signaling pathway; suppression by virus of host apoptosis; ADP metabolic process; positive regulation of insulin secretion; ATP metabolic process; glucose catabolic process; cell proliferation; positive regulation of T cell differentiation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of B cell differentiation; regulation of mitochondrial membrane permeability; positive regulation of epithelial cell proliferation
尺寸1 :
0.05毫升
价格1 :
235美元
尺寸2 :
0.1毫升
价格2 :
350
size3 :
0.2毫升
价格3 :
525
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。