产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Mouse Anti Human Macrophage/Monocyte Chemotactic & Activating Factor
目录 :
MBS140020
规格 :
0.5毫克
价格 :
230美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
YNR-HMCAF
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫沉淀, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS140020
产品类型 :
抗体
产品全称 :
Mouse Anti Human Macrophage/Monocyte Chemotactic & Activating Factor
产品简称 :
Macrophage/Monocyte Chemotactic & Activating Factor
产品名称同义词 :
MCP 1 Antibody; Macrophage/Monocyte Chemotactic & Activating Factor, Mouse Anti-Human; Small inducible cytokine A2; CCL2; Monocyte chemotactic protein 1; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte secretory protein JE; HC11; chemokine (C-C motif) ligand 2; MCP1; SCYA2; GDCF-2; SMC-CF; HSMCR30; MGC9434; GDCF-2 HC11
其他名称 :
C-C motif chemokine 2; C-C motif chemokine 2; C-C motif chemokine 2; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; monocyte secretory protein JE; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small-inducible cytokine A2; chemokine (C-C motif) ligand 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2
产品基因名称 :
MCP-1
其他基因名称 :
CCL2;CCL2;HC11;MCAF;MCP1;MCP-1;SCYA2;GDCF-2;SMC-CF;HSMCR30;MCP1;SCYA2;MCAF;MCP-1
UniProt数据库进入名 :
CCL2_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2a
克隆 :
YNR-HMCAF
宿主 :
小鼠
序列长度 :
99
纯度 :
离子交换
浓度 :
1mg/ml in PBS (after reconstitution) Shipping ConditionsAntibody is shipped lyophilized at ambient temperature.
储存稳定性 :
In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)
应用笔记 :
Direct ELISA, Western Blot, Immunoprecipitation. In direct ELISA, using alkaline phosphatase goat anti-mouse Ig (Jackson Laboratories) 1:5,000 dilution will give 0.3 O.D within 10 minutes.
其他信息2 :
Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Note: MCAF does not bind to plastic as good as most proteins - use higher concentration for proper binding. Immunogen: r.Human MCAF.
产品种类 :
单克隆抗体, 抗人类CHEMOKINES;单克隆抗体;抗人类趋化因子
产品描述 :
Introduction: Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B (NF?B). CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.
NCBI GI登录号 :
4506841
NCBI登录号 :
NP_002973.1
NCBI基因登录号 :
NM_002982.3
NCBI分子量 :
11,025 Da
NCBI信号通路 :
ATF4 Activates Genes Pathway 530772!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664
NCBI总结 :
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
规格 :
0.5毫克
价格 :
230美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。