产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
小鼠抗人类CD44
目录 :
MBS140142
规格 :
0.5毫克
价格 :
230美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
hCD44
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
MBS140142
产品类型 :
抗体
产品全称 :
小鼠抗人类CD44
产品简称 :
CD44
产品名称同义词 :
CD44 Antibody; CD44, Mouse Anti-Human; MDU2; MDU3; MIC4; CDW44; CSPG8; HCELL; HUTCH-I; Phagocytic glycoprotein I; PGP-1; Extracellular matrix receptor-III; ECMR-III; Hermes antigen; Hyaluronate receptor; Heparan sulfate proteoglycan; Epican) CDw44
其他名称 :
CD44 antigen isoform 1; CD44 antigen; CD44 antigen; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; epican; extracellular matrix receptor III; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; homing function and Indian blood group system; hyaluronate receptor; phagocytic glycoprotein 1; CD44 molecule (Indian blood group); CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
产品基因名称 :
CD44
其他基因名称 :
CD44;CD44;在;LHR;MC56;MDU2;MDU3;MIC4;Pgp1;CDW44;CSPG8;HCELL;HUTCH-I;ECMR-III;LHR;MDU2;MDU3;MIC4;ECMR-III;PGP-1;PGP-I
UniProt数据库进入名 :
CD44_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
hCD44
宿主 :
小鼠
序列长度 :
742
纯度 :
蛋白质A
浓度 :
1mg/ml in PBS (after reconstitution).
储存稳定性 :
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
其他信息2 :
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: Purified human T-Cells. Antibody Properties: Staining antibody. For staining, use 10 ul/1,000,000 cells. Available Conjugates: This antibody is also available conjugated to biotin and FITC. For staining with biotin or FITC-conjugated antibody use 5-10 ul/106 cells.
产品种类 :
单克隆抗体, 抗人类LYMPHOCYTES;单克隆抗体;抗人类淋巴细胞
产品描述 :
Introduction: CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions, cell adhesion and migration. CD44 is a receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. CD44 participates in a wide variety of cellular functions such as lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44 and CD49d are putative activity markers and CD44 a potential novel therapeutic target in multiple sclerosis. Increased CD44 antigen is associated with relapses in non-small cell lung cancers.
NCBI GI登录号 :
48255935
NCBI登录号 :
NP_000601.3
NCBI基因登录号 :
NM_000610.3
NCBI分子量 :
15,635 Da
NCBI信号通路 :
Cell Surface Interactions At The Vascular Wall Pathway (106062); Cytokine Signaling In Immune System Pathway (366171); Defective B3GAT3 Causes JDSSDHD Pathway (1127588); Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway (1127592); Defective B4GALT7 Causes EDS, Progeroid Type Pathway (1127587); Defective CHST14 Causes EDS, Musculocontractural Type Pathway (1127591); Defective CHST3 Causes SEDCJD Pathway (1127590); Defective CHST6 Causes MCDC1 Pathway (1127593); Defective CHSY1 Causes TPBS Pathway (1127589); Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway (1127594)
NCBI总结 :
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion; Receptor, misc. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: Golgi apparatus; cell surface; focal adhesion; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane. Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; hyaluronic acid binding; hyalurononglucosaminidase activity. Biological Process: extracellular matrix organization and biogenesis; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; glycosaminoglycan metabolic process; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; pathogenesis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; extracellular matrix disassembly; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell adhesion; ureteric bud branching; cartilage development; carbohydrate metabolic process; blood coagulation; hyaluronan metabolic process; leukocyte migration; healing during inflammatory response; negative regulation of apoptosis. Disease: Blood Group, Indian System
尺寸1 :
0.5毫克
价格1 :
230美元
尺寸2 :
1毫克
价格2 :
350
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。