蛋白

重组人类鸟嘌呤核苷酸结合蛋白

MBS141135

0.005毫克

140美元

重组蛋白

重组人类鸟嘌呤核苷酸结合蛋白

[鸟嘌呤核苷酸结合蛋白]

[GNAQ Human; Guanine Nucleotide Binding Protein Human Recombinant; Guanine Nucleotide Binding Protein (G Protein); Q Polypeptide; Guanine Nucleotide-Binding Protein Alpha-Q; CMC1; SWS; GAQ; Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha; G-ALPHA-Q; Guanine nucleotide-binding protein G(q) subunit alpha]

[鸟嘌呤核苷酸结合蛋白G(q)亚单位甲;鸟嘌呤核苷酸结合蛋白G(q)亚单位甲;鸟嘌呤核苷酸结合蛋白G(q)亚单位甲;G蛋白亚单位甲q;鸟嘌呤核苷酸结合蛋白甲q]

[GNAQ]

[GNAQ;GNAQ;GAQ;SWS;CMC1;G-甲;GAQ]

GNAQ_HUMAN

大肠杆菌

359

MGSSHHHHHH SSGLVPRGSH MGS MTLESIM ACCLSEEAKE ARRINDEIER QLRRDKRDAR RELKLLLLGTGESGKSTFIK QMRIIHGSGY SDEDKRGFTK LVYQNIFTAM QAMIRAMDTL KIPYKYEHNK AHAQLVREVDVEKVSAFENP YVDAIKSLWN DPGIQECYDR RREYQLSDSTKYYLNDLDRV ADPAYLPTQQ DVLRVRVPTT GIIEYPFDLQ SVIFRMVDVGGQRSERRKWI HCFENVTSIM FLVALSEYDQ VLVESDNENR MEESKALFRT IITYPWFQNS SVILFLNKKDLLEEKIMYSH LVDYFPEYDG PQRDAQAARE FILKMFVDLN PDSDKIIYSH FTCATDTENIRFVFAAVKDT ILQLNLKEYN LV

Greater than 90.0% as determined by SDS-PAGE.

GNAQ蛋白溶液(0.5毫克/毫升)含20mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0), 0.4M尿素和10% 甘油

Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to ass a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Physical Appearance: Sterile Filtered clear solution

重组&NATURAL PROTEINS

Introduction: GNAQ, also known as Guanine nucleotide-binding protein belong to the G-alpha family. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in a variety of transmembrane signaling systems. GNAQ regulates B-cell selection and survival and is essential in order to prevent B-cell-dependent autoimmunity. GNAQ also regulates chemotaxis of BM-derived neutrophils and dendritic cells, in vitro. GNAQ is an alpha subunit in the Gq class,. Description: GNAQ Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 382 amino acids (1-359 a.a) and having a molecular mass of 44.5kDa. GNAQ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

40254462

NP_002063.2

NM_002072.4

P50148

42,142 Da

ADP Signalling Through P2Y Purinoceptor 1 Pathway (1269354); Acetylcholine Regulates Insulin Secretion Pathway (1270104); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509)

G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q). Chromosomal Location of Human Ortholog: 9q21. Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane. Molecular Function: GTPase activator activity; GTPase activity; protein binding; type 2A serotonin receptor binding. Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; negative regulation of protein kinase activity; phospholipase C activation; phototransduction, visible light; platelet activation; protein stabilization; regulation of action potential. Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome

0.005毫克

140美元

0.02毫克

205

1毫克

2665