产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
重组人类免疫沉淀-10(CXCL10), 多聚组氨酸标签
目录 :
MBS142053
规格 :
0.005毫克
价格 :
140美元
更多信息或购买 :
产品信息
目录号 :
MBS142053
产品类型 :
重组蛋白
产品全称 :
重组人类免疫沉淀-10(CXCL10), 多聚组氨酸标签
产品简称 :
免疫沉淀-10
产品名称同义词 :
IP 10 Human, His; IP-10 Human Recombinant (CXCL10), His Tag; Small inducible cytokine B10; CXCL10; 10 kDa interferon-gamma-induced protein; Gamma-IP10; IP-10; chemokine (C-X-C motif) ligand 10; C7; IFI10; INP10; crg-2; mob-1; SCYB10; gIP-10
其他名称 :
C-X-C motif chemokine 10; C-X-C motif chemokine 10; C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; gamma IP10; gamma-IP10; interferon-inducible cytokine IP-10; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10; chemokine (C-X-C motif) ligand 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10CXCL10(1-73)
产品基因名称 :
IP 10 His
其他基因名称 :
CXCL10; CXCL10; C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; INP10; SCYB10; Gamma-IP10; IP-10
UniProt数据库进入名 :
CXL10_HUMAN
宿主 :
大肠杆菌
序列长度 :
98
纯度 :
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
形式 :
IP-10 His is supplied in 10mM Tris HCl pH8, 1mM EDTA and 50% glycerol. Sterile Filtered clear solution.
浓度 :
1x25微克/250微升
储存稳定性 :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
产品种类 :
CHEMOKINES;趋化因子;免疫沉淀-10(CXCL10)
产品描述 :
Description: IP-10 His Tag Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment (22-98) and having a total molecular mass of 8.5 kDa with an amino-terminal hexahistidine tag. The IP-10 His is purified by proprietary chromatographic techniques. Introduction: Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (?-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes, endothelial cellsand fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytesand T cells, promotion of T cell adhesion to endothelial cells, anti tumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.
NCBI GI登录号 :
149999382
NCBI登录号 :
NP_001556.2
NCBI基因登录号 :
NM_001565.3
UniProt数据库登录号 :
P02778
NCBI分子量 :
10,881 Da
NCBI信号通路 :
CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664)
NCBI总结 :
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
UniProt数据库总结 :
CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: extracellular space; extracellular region; external side of plasma membrane. Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding. Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; immune response; positive regulation of transcription from RNA polymerase II promoter; response to cold; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; regulation of protein kinase activity; negative regulation of myoblast differentiation; defense response to virus
尺寸1 :
0.005毫克
价格1 :
140美元
尺寸2 :
0.025毫克
价格2 :
205
size3 :
1毫克
价格3 :
3465
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。