产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
重组人类血管内皮生长因子(121), Sf9
目录 :
MBS142077
规格 :
0.01毫克
价格 :
205美元
更多信息或购买 :
产品信息
目录号 :
MBS142077
产品类型 :
重组蛋白
产品全称 :
重组人类血管内皮生长因子(121), Sf9
产品简称 :
血管内皮生长因子
产品名称同义词 :
血管内皮生长因子(121 a.a。)人类, Sf9;血管内皮生长因子(121 a.a。)人类重组, Sf9;血管内皮生长因子;血管内皮生长因子-A;血管通透性因子;VPF;血管内皮生长因子;MGC70609;血管内皮生长因子(121a.a。)Sf9
其他名称 :
vascular endothelial growth factor A isoform a; Vascular endothelial growth factor A; vascular endothelial growth factor A; vascular permeability factor; vascular endothelial growth factor A; Vascular permeability factor; VPF
产品基因名称 :
血管内皮生长因子
其他基因名称 :
血管内皮生长因子A;血管内皮生长因子A;VPF;血管内皮生长因子;MVCD1;血管内皮生长因子;血管内皮生长因子-A;VPF
UniProt数据库进入名 :
VEGFA_HUMAN
宿主 :
Sf9昆虫细胞
序列长度 :
412
序列 :
CVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHN KCECRPKKDRARQEKCDKPRR.
APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEY
PDEIEYIFKPS
纯度 :
Greater than 95.0% as determined by SDS-PAGE.
形式 :
The protein was lyophilized from a solution containing 50mM acetic acid. Sterile Filtered White lyophilized (freeze-dried) powder.
储存稳定性 :
Lyophilized Vascular Endothelial Growth Factor 121 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution VEGF-121 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
其他信息2 :
Solubility: The lyophilized VEGF121 should be reconstituted in 50mM acetic acid to a concentration not lower than 50 ug/ml. Biological Activity: The ED50 for stimulation of 3H-thymidine incorporation and cell proliferation by human umbilical vein endothelial cells for VEGF121 has been determined to be in the range of 1-4 ng/ml.
产品种类 :
CYTOKINES和增长FACTORS;生长因子;血管内皮生长因子
产品描述 :
Description: Vascular Endothelial Growth Factor-121 Human Recombinant produced in insect cells as an 18kDa homodimer, is a glycosylated, polypeptide chain containing 121 amino acids and having a molecular mass of approximately 36kDa.VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates.The VEGF-121 is purified by proprietary chromatographic techniques. Introduction: Vascular endothelial growth factor is an important signaling protein involved in both vasculogenesis and angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/ macrophagemigration, neurons, cancer cells, kidney epithelial cells).VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesisand cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.Elevated levels of this protein are linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.
NCBI GI登录号 :
76781480
NCBI登录号 :
NP_001020537.2
NCBI基因登录号 :
NM_001025366.2
UniProt数据库登录号 :
P15692
NCBI分子量 :
34,406 Da
NCBI信号通路 :
Angiogenesis Pathway 198772!!Axon Guidance Pathway 105688!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cellular Response To Hypoxia Pathway 645259!!Cellular Responses To Stress Pathway 645258!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Developmental Biology Pathway 477129!!EPH-Ephrin Signaling Pathway 1127691
NCBI总结 :
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
规格 :
0.01毫克
价格 :
205美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。