蛋白

重组人类丝裂原活化蛋白激酶1, 活性的

MBS142760

0.001毫克

140美元

重组蛋白

重组人类丝裂原活化蛋白激酶1, 活性的

[丝裂原活化蛋白激酶1]

[MAPK1 Human, Active; Mitogen-Activated Protein Kinase 1 Human Recombinant, Active; Mitogen-activated protein kinase 1; EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1; ERK; p38; p40; p41; ERK2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; MAPK1 Active]

[mitogen-activated protein kinase 1; Mitogen-activated protein kinase 1; mitogen-activated protein kinase 1; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; protein tyrosine kinase ERK2; mitogen-activated protein kinase 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2]

[MAPK1]

[MAPK1;MAPK1;ERK;p38;p40;p41;ERK2;ERT1;ERK-2;MAPK2;PRKM1;PRKM2;丝裂原活化蛋白激酶P42;p41mapk;p42-MAPK;ERK2;PRKM1;PRKM2;地图激酶1;MAPK 1;ERK-2;p42-MAPK;地图激酶2;MAPK 2]

MK01_HUMAN

大肠杆菌

360

maaaaaagag pemvrgqvfd vgprytnlsy igegaygmvc saydnvnkvr vaikkispfe hqtycqrtlr eikillrfrh eniigindii raptieqmkd vyivqdlmet dlykllktqh lsndhicyfl yqilrglkyi hsanvlhrdl kpsnlllntt cdlkicdfgl arvadpdhdh tgflteyvat rwyrapeiml nskgytksid iwsvgcilae mlsnrpifpg khyldqlnhi lgilgspsqe dlnciinlka rnyllslphk nkvpwnrlfp nadskaldll dkmltfnphk rieveqalah pyleqyydps depiaeapfk fdmelddlpk eklkelifee tarfqpgyrs

Greater than 95.0% as determined by SDS-PAGE.

MAPK1 is supplied containing 50mM Tris-HCL, 150mM NaCl, 1mM DTT, 50% glycerol, pH 8.5. Sterile Filtered clear solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

Unit Defenition: 1 U = 1 pmol/min transferred to myelin basic protein at 30 degree C. Specific Activity: Specific Activity is 470.000 Units/mg.

蛋白KINASES;酶;丝裂原活化蛋白激酶

Description: MAPK1 Recombinant (extracellular signal-regulated kinase) a Mitogen-Activated Protein Kinase, is a highly active form produced by phosphorylation of the purified ERK2/MAPK1 in vitro with MEK1 is a non-glycosylated polypeptide chain containing amino acids 2-480 and having a molecular mass of 44.6 kDa. MAPK1 contains an amino terminal polyhistidine tag and is purified by proprietary chromatographic techniques. Introduction: Mitogen-activated protein kinase 1 (MAPK1) is also known as "extracellular signal-regulated kinase 2" (ERK2). Two similar (85% sequence identity) protein kinases were originally called ERK1 and ERK2. They were found during a search for protein kinases that are rapidly phosphorylated after activation of cell surface tyrosine kinasessuch as the epidermal growth factor receptor. Phosphorylation of ERKs leads to the activation of their kinase activity.The molecular events linking cell surface receptors to activation of ERKs are complex. It was found that RasGTP-binding proteins are involved in the activation of ERKs. Another protein kinase, Raf-1, was shown to phosphorylate a "MAPK kinase", thus qualifying as a "MAPK kinase kinase". The MAPK kinase was named "MAPK/ERK kinase" (MEK). Receptor-linked tyrosine kinases, Ras, Raf, MEK and MAPK could be fitted into a signaling cascade linking an extracellular signal to MAPK activation.Transgenic gene knockoutmice lacking MAPK1 have major defects in early development.

66932916

NP_002736.3

NM_002745.4

P28482

36,432 Da

AGE/RAGE Pathway (698754); ALK1 Signaling Events Pathway (137968); ARMS-mediated Activation Pathway (106466); ATF-2 Transcription Factor Network Pathway (138006); Activated TLR4 Signalling Pathway (106400); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Activation Of The AP-1 Family Of Transcription Factors Pathway (160139); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adherens Junction Pathway (83070)

0.001毫克

140美元

0.005毫克

205

0.1毫克

1995