产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
重组人类丝裂原活化蛋白激酶1
目录 :
MBS142761
规格 :
0.002毫克
价格 :
140美元
更多信息或购买 :
产品信息
目录号 :
MBS142761
产品类型 :
重组蛋白
产品全称 :
重组人类丝裂原活化蛋白激酶1
产品简称 :
丝裂原活化蛋白激酶1
产品名称同义词 :
MAPK1 Human; Mitogen-Activated Protein Kinase 1 Human Recombinant; Mitogen-activated protein kinase 1; EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1; ERK; p38; p40; p41; ERK2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk
其他名称 :
mitogen-activated protein kinase 1; Mitogen-activated protein kinase 1; mitogen-activated protein kinase 1; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; protein tyrosine kinase ERK2; mitogen-activated protein kinase 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2
产品基因名称 :
MAPK1
其他基因名称 :
MAPK1;MAPK1;ERK;p38;p40;p41;ERK2;ERT1;ERK-2;MAPK2;PRKM1;PRKM2;丝裂原活化蛋白激酶P42;p41mapk;p42-MAPK;ERK2;PRKM1;PRKM2;地图激酶1;MAPK 1;ERK-2;p42-MAPK;地图激酶2;MAPK 2
UniProt数据库进入名 :
MK01_HUMAN
宿主 :
大肠杆菌
序列长度 :
360
纯度 :
Greater than 95.0% as determined by SDS-PAGE.
形式 :
MAPK1 is supplied containing 50mM Tris-HCL, 150mM NaCl, 2mM DTT, pH 8.0, 100 Units*/mg. Sterile Filtered clear solution.
浓度 :
1毫克/3.75毫升
储存稳定性 :
MAPK1 should be stored at 4 degree C if entire vial will be used within 2-4 weeks. For long term storage it is recommended to store at -20 degree C. Avoid multiple freeze-thaw cycles.
其它信息1 :
Unit Defenition: 1 U = 1 pmol/min transferred to myelin basic protein at 30 degree C.
产品种类 :
蛋白KINASES;酶;丝裂原活化蛋白激酶
产品描述 :
Description: MAPK1 Recombinant (extracellular signal-regulated kinase) a Mitogen-Activated Protein Kinase, is a highly active form produced by phosphorylation of the purified ERK2/MAPK1 in vitro with MEK1 is a non-glycosylated polypeptide having a molecular mass of 44.6 kDa. MAPK1 is purified by proprietary chromatographic techniques. Introduction: Mitogen-activated protein kinase 1 (MAPK1) is also known as "extracellular signal-regulated kinase 2" (ERK2). Two similar (85% sequence identity) protein kinases were originally called ERK1 and ERK2. They were found during a search for protein kinases that are rapidly phosphorylated after activation of cell surface tyrosine kinasessuch as the epidermal growth factor receptor. Phosphorylation of ERKs leads to the activation of their kinase activity.The molecular events linking cell surface receptors to activation of ERKs are complex. It was found that RasGTP-binding proteins are involved in the activation of ERKs. Another protein kinase, Raf-1, was shown to phosphorylate a "MAPK kinase", thus qualifying as a "MAPK kinase kinase". The MAPK kinase was named "MAPK/ERK kinase" (MEK). Receptor-linked tyrosine kinases, Ras, Raf, MEK and MAPK could be fitted into a signaling cascade linking an extracellular signal to MAPK activation.Transgenic gene knockoutmice lacking MAPK1 have major defects in early development.
NCBI GI登录号 :
66932916
NCBI登录号 :
NP_002736.3
NCBI基因登录号 :
NM_002745.4
UniProt数据库登录号 :
P28482
NCBI分子量 :
36,432 Da
NCBI信号通路 :
AGE/RAGE Pathway (698754); ALK1 Signaling Events Pathway (137968); ARMS-mediated Activation Pathway (106466); ATF-2 Transcription Factor Network Pathway (138006); Activated TLR4 Signalling Pathway (106400); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Activation Of The AP-1 Family Of Transcription Factors Pathway (160139); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adherens Junction Pathway (83070)
NCBI总结 :
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
UniProt数据库总结 :
ERK2: a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.24; Kinase, protein; Protein kinase, CMGC; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily. Chromosomal Location of Human Ortholog: 22q11.21. Cellular Component: dendrite cytoplasm; Golgi apparatus; protein complex; focal adhesion; mitochondrion; early endosome; perikaryon; pseudopodium; caveola; cytosol; microtubule cytoskeleton; nucleoplasm; cytoskeleton; axon; late endosome; cytoplasm; microtubule organizing center; nucleus. Molecular Function: MAP kinase activity; RNA polymerase subunit kinase activity; protein serine/threonine kinase activity; protein binding; DNA binding; phosphotyrosine binding; mitogen-activated protein kinase kinase kinase binding; transcription factor binding; ATP binding; phosphatase binding. Biological Process: activation of MAPKK activity; nerve growth factor receptor signaling pathway; viral reproduction; activation of MAPK activity; response to toxin; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; sensory perception of pain; T cell receptor signaling pathway; protein amino acid phosphorylation; toll-like receptor 5 signaling pathway; B cell receptor signaling pathway; regulation of transcription factor activity; small GTPase mediated signal transduction; toll-like receptor 4 signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; toll-like receptor 2 signaling pathway; regulation of stress-activated MAPK cascade; organ morphogenesis; nuclear translocation of MAPK; response to estrogen stimulus; toll-like receptor 9 signaling pathway; regulation of cytoskeleton organization and biogenesis; axon guidance; positive regulation of translation; apoptosis; regulation of protein stability; signal transduction; chemotaxis; toll-like receptor 10 signaling pathway; synaptic transmission; response to exogenous dsRNA; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; response to stress; epidermal growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; peptidyl-threonine phosphorylation; MAPKKK cascade; mammary gland epithelial cell proliferation; cell cycle; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cell differentiation; peptidyl-serine phosphorylation; cytosine metabolic process; Ras protein signal transduction; toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation; response to DNA damage stimulus; positive regulation of cell migration
尺寸1 :
0.002毫克
价格1 :
140美元
尺寸2 :
0.01毫克
价格2 :
205
size3 :
0.1毫克
价格3 :
1125
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。