蛋白

Recombinant Human Osteocrin

MBS142974

0.002毫克

140美元

重组蛋白

Recombinant Human Osteocrin

Osteocrin

Osteocrin Human; Osteocrin Human Recombinant; Osteocrin; Musclin; OSTN; Osteocrin

osteocrin; Osteocrin; osteocrin; osteocrin; Musclin

OSTN;OSTN;MUSCLIN

OSTN_HUMAN

大肠杆菌

133

Greater than 95% as determined by SDS-PAGE.

Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer, pH 4.0. Filtered White lyophilized (freeze-dried) powder.

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Solubility: It is recommended to add 0.1M Acetate buffer pH4 to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

重组&NATURAL PROTEINS;重组蛋白

Description: The recombinant Human Osteocrin is produced with N-terminal fusion of His Tag. The Human Osteocrin His-Tagged Fusion Protein is 13.6 kDa containing 106 amino acid residues of the human Osteocrin and 16 additional amino acid residues His Tag (underlined). Introduction: Osteocrin is a recently identified secreted protein expression of which was only detected in bone, peaking just after birth and decreasing markedly with age. A 1280-bp mRNA encodes osteocrin producing a mature protein of 103 amino acids with a molecular mass of 11.4 kDa. In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures. Treatment of cultures with 1,25-dihydroxyvitamin D3 resulted in a rapid dose- dependent down-regulation of osteocrin expression, suggesting direct regulation. Chronic treatment of primary cultures with osteocrin-conditioned media inhibited mineralization and reduced osteocalcin and alkaline phosphatase expression. These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.

38044108

NP_937827.1

NM_198184.1

P61366

14,722 Da

OSTN: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q28. Cellular Component: extracellular space. Molecular Function: hormone activity. Biological Process: negative regulation of glucose import; ossification; cell surface receptor linked signal transduction; positive regulation of cGMP biosynthetic process; negative regulation of osteoblast differentiation; cell differentiation

0.002毫克

140美元

0.01毫克

205

1毫克

4140