产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
重组人类钙粘蛋白E
目录 :
MBS143015
规格 :
0.002毫克
价格 :
265美元
更多信息或购买 :
产品信息
目录号 :
MBS143015
产品类型 :
重组蛋白
产品全称 :
重组人类钙粘蛋白E
产品简称 :
钙粘蛋白E
产品名称同义词 :
Cadherin-E Human; Cadherin-E Human Recombinant; Epithelial cadherin; E-cadherin; Uvomorulin; Cadherin-1; CAM 120/80; CD324 antigen; CDH1; CDHE; UVO; ECAD; LCAM; Arc-1; CD324; Cadherin-E; Cadherin-E
其他名称 :
cadherin-1 preproprotein; Cadherin-1; cadherin-1; CAM 120/80; E-Cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; cell-CAM 120/80; epithelial cadherin; uvomorulin; cadherin 1, type 1, E-cadherin (epithelial); CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD_antigen: CD324Cleaved into the following 3 chains:E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3
其他基因名称 :
CDH1; CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDHE; UVO; E-cadherin
UniProt数据库进入名 :
CADH1_HUMAN
宿主 :
大肠杆菌
序列长度 :
882
序列 :
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形式 :
Cadherin-E protein (100 ug/1ml) in 50mM Tris-HCl, pH7.5 and 10mM L-glutathione (reduced). Sterile Filtered clear solution.
储存稳定性 :
Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.
产品种类 :
重组&NATURAL PROTEINS;重组蛋白
产品描述 :
Description: Cadherin-E Human Recombinant (aa 600-707) expressed in E Coli, shows a 38 kDa band on SDS-PAGE.The Cadherin-E is purified by proprietary chromatographic techniques. Introduction: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of Ecadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
NCBI GI登录号 :
4757960
NCBI登录号 :
NP_004351.1
NCBI基因登录号 :
NM_004360.3
UniProt数据库登录号 :
P12830
NCBI分子量 :
90,942 Da
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (119533); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Arf6 Trafficking Events Pathway (137954); Bacterial Invasion Of Epithelial Cells Pathway (149807)
NCBI总结 :
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CDH1: a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis. Has a potent invasive suppressor role. Protein type: Ubiquitin ligase; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16q22.1. Cellular Component: apical junction complex; internal side of plasma membrane; focal adhesion; cell surface; basolateral plasma membrane; lateral loop; integral to membrane; extracellular region; trans-Golgi network; catenin complex; actin cytoskeleton; cell-cell adherens junction; perinuclear region of cytoplasm; apical part of cell; cytoplasm; plasma membrane; nerve terminal; cell junction; lateral plasma membrane; endosome. Molecular Function: protein domain specific binding; protein binding; gamma-catenin binding; beta-catenin binding; GTPase activating protein binding; ankyrin binding; calcium ion binding; cell adhesion molecule binding; glycoprotein binding; protein phosphatase binding. Biological Process: response to drug; intercellular junction assembly and maintenance; extracellular matrix organization and biogenesis; regulation of immune response; apoptosis; response to toxin; positive regulation of transcription, DNA-dependent; regulation of caspase activity; trophectodermal cell differentiation; regulation of water loss via skin; extracellular matrix disassembly; cell-cell adhesion; sensory perception of sound; synaptogenesis; pituitary gland development; calcium-dependent cell-cell adhesion; protein metabolic process; positive regulation of transcription factor import into nucleus; negative regulation of cell-cell adhesion; homophilic cell adhesion; protein homooligomerization; neurite development; cell structure disassembly during apoptosis; negative regulation of epithelial cell proliferation. Disease: Gastric Cancer, Hereditary Diffuse; Breast Cancer; Prostate Cancer; Ovarian Cancer; Endometrial Cancer
尺寸1 :
0.002毫克
价格1 :
265美元
尺寸2 :
0.005毫克
价格2 :
365
size3 :
0.01毫克
价格3 :
610
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。