产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
人类纤溶酶原激活物抑制因子1
目录 :
MBS143202
规格 :
0.002毫克
价格 :
140美元
更多信息或购买 :
产品信息
目录号 :
MBS143202
产品类型 :
天然蛋白
产品全称 :
人类纤溶酶原激活物抑制因子1
产品简称 :
纤溶酶原激活物抑制因子1
产品名称同义词 :
SERPINE1人类;纤溶酶原激活物抑制因子1人类;PAI-1;PAI1;PLANH1;SERPINE1;PAIE;纤溶酶原激活剂INHIBITOR;乙-MIGRATING ENDOTHELIAL-细胞类型
其他名称 :
plasminogen activator inhibitor 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1
产品基因名称 :
SERPINE1
其他基因名称 :
SERPINE1;SERPINE1;PAI;PAI1;PAI-1;PLANH1;PAI1;PLANH1;PAI;PAI-1
UniProt数据库进入名 :
PAI1_HUMAN
序列长度 :
402
纯度 :
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
形式 :
0.05M sodium phosphate 0.1M NaCl and 1mM EDTA (pH 6.6). Sterile Filtered clear colorless solution.
储存稳定性 :
Human SERPINE1 although stable at 8 degree C celsius for 1 week, should be stored desiccated below -18 degree C.
产品种类 :
ENZYMES;重组蛋白;丝氨酸蛋白酶抑制剂
产品描述 :
Description: Constitutively active human plasminogen activator inhibitor 1, stable mutant 14-1B having a Molecular mass of 43 kDa. This human form of SERPINE1 contains the following four mutations: K154T, Q139L, M354I and N150H. These mutations combine to confer great stability to the otherwise labile molecule essentially locking it into the active conformation. The SERPINE1 is purified by proprietary chromatographic techniques. Introduction: Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator(tPA) and urokinase(uPA), the activators of plasminogenand hence fibrinolysis(the physiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2(PAI-2) is secreted by the placentaand only present in significant amounts during pregnancy. In addition, protease nexinacts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
NCBI GI登录号 :
10835159
NCBI登录号 :
NP_000593.1
NCBI基因登录号 :
NM_000602.4
UniProt数据库登录号 :
P05121
NCBI分子量 :
43,404 Da
NCBI信号通路 :
Adipogenesis Pathway (198832); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Blood Clotting Cascade Pathway (198840); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Circadian Clock Pathway (187173); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Direct P53 Effectors Pathway (137939)
NCBI总结 :
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt数据库总结 :
SERPINE1: a secreted protein that acts as bait for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7q22.1. Cellular Component: extracellular matrix; extracellular space; extracellular region; plasma membrane. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; receptor binding. Biological Process: circadian rhythm; extracellular matrix organization and biogenesis; positive regulation of blood coagulation; negative regulation of smooth muscle cell migration; defense response to Gram-negative bacterium; positive regulation of receptor-mediated endocytosis; positive regulation of interleukin-8 production; platelet degranulation; negative regulation of fibrinolysis; transforming growth factor beta receptor signaling pathway; regulation of receptor activity; angiogenesis; chronological cell aging; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; platelet activation; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of blood coagulation; regulation of cell proliferation; fibrinolysis; positive regulation of angiogenesis; gene expression; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; positive regulation of inflammatory response. Disease: Plasminogen Activator Inhibitor-1 Deficiency
尺寸1 :
0.002毫克
价格1 :
140美元
尺寸2 :
0.01毫克
价格2 :
205
size3 :
1毫克
价格3 :
3490
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。