产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
重组人类亲环素A
目录 :
MBS143205
规格 :
0.01毫克
价格 :
140美元
更多信息或购买 :
产品信息
目录号 :
MBS143205
产品类型 :
重组蛋白
产品全称 :
重组人类亲环素A
产品简称 :
亲环素A
产品名称同义词 :
Cyclophilin A Human; Cyclophilin-A Human Recombinant; Peptidylprolyl isomerase A; CYPA; CYPH; MGC12404; MGC23397; MGC117158; PPIase A; Rotamase A; PPIA; Peptidyl-prolyl cis-trans isomerase A; EC 5.2.1.8; Cyclophilin A; Cyclosporin A-binding protein; Cyclophilin A
其他名称 :
peptidyl-prolyl cis-trans isomerase A isoform 2; Peptidyl-prolyl cis-trans isomerase A; peptidyl-prolyl cis-trans isomerase A; PPIase A; T cell cyclophilin; cyclosporin A-binding protein; epididymis secretory sperm binding protein Li 69p; rotamase A; peptidylprolyl isomerase A (cyclophilin A); Cyclophilin A; Cyclosporin A-binding protein; Rotamase APeptidyl-prolyl cis-trans isomerase A, N-terminally processed
其他基因名称 :
PPIA;PPIA;CYPA;CYPH;HEL-S-69p;CYPA;PPIase A
UniProt数据库进入名 :
PPIA_HUMAN
宿主 :
大肠杆菌
序列长度 :
105
序列 :
MGSSHHHHHH SSGLVPRGSH MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALSTGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSMANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIADCGQLE
纯度 :
Greater than 95.0% as determined by SDS-PAGE.
形式 :
1 mg/ml solution containing 20mM Tris-HCl 8.0, 20mM NaCl, 0.5mM DTT and 10% glycerol. Sterile filtered colorless solution.
其他信息2 :
Biological Activity: Specific activity is > 270 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.
产品种类 :
ENZYMES;酶;亲环素类
产品描述 :
Description: Cyclophilin-A Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 185 amino acids (1-165 a.a.) and having a molecular mass of 20 kDa. PPIase-A is purified by proprietary chromatographic techniques. Introduction: PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilin-A is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. Cyclophilin-A can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
NCBI GI登录号 :
665821274
NCBI登录号 :
NP_001287910.1
NCBI基因登录号 :
NM_001300981.1
UniProt数据库登录号 :
P62937
NCBI分子量 :
11,418 Da
NCBI信号通路 :
APOBEC3G Mediated Resistance To HIV-1 Infection Pathway (106016); Assembly Of The HIV Virion Pathway (106008); Basigin Interactions Pathway (106065); Binding And Entry Of HIV Virion Pathway (105986); Budding And Maturation Of HIV Virion Pathway (106009); Cell Surface Interactions At The Vascular Wall Pathway (106062); Disease Pathway (530764); Early Phase Of HIV Life Cycle Pathway (105985); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984)
NCBI总结 :
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. Protein type: EC 5.2.1.8; Cyclophilin; Isomerase; RNA-binding. Chromosomal Location of Human Ortholog: 7p13. Cellular Component: extracellular space; focal adhesion; membrane; extracellular region; cytosol; nucleus. Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; virion binding; peptide binding. Biological Process: release of virus from host; platelet activation; uncoating of virus; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; protein folding; viral reproduction; RNA-dependent DNA replication; viral infectious cycle; virus assembly; platelet degranulation; positive regulation of protein secretion; entry into host cell; blood coagulation; leukocyte migration; regulation of viral genome replication
尺寸1 :
0.01毫克
价格1 :
140美元
尺寸2 :
0.05毫克
价格2 :
205
size3 :
1毫克
价格3 :
2365
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。
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