产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
重组人类SMAC/DIABLO
目录 :
MBS143447
规格 :
0.02毫克
价格 :
205美元
更多信息或购买 :
产品信息
目录号 :
MBS143447
产品类型 :
重组蛋白
产品全称 :
重组人类SMAC/DIABLO
产品简称 :
SMAC/DIABLO
产品名称同义词 :
SMAC/DIABLO Human; SMAC/DIABLO Human Recombinant; Diablo homolog mitochondrial; Second mitochondria-derived activator of caspase; Smac protein; Direct IAP-binding protein with low pI; DIABLO; SMAC; SMAC3; DIABLO-S; FLJ10537; FLJ25049
其他名称 :
diablo homolog, mitochondrial isoform 4; Diablo homolog, mitochondrial; diablo homolog, mitochondrial; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase; diablo, IAP-binding mitochondrial protein; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac
产品基因名称 :
SMAC/DIABLO
其他基因名称 :
DIABLO; DIABLO; SMAC; DFNA64; SMAC; Smac
UniProt数据库进入名 :
DBLOH_HUMAN
宿主 :
大肠杆菌
序列长度 :
142
序列 :
MASMTGGQQM GRGSMAVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED
纯度 :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
形式 :
The Smac/Diablo solution contains 20mM Tris pH-7.5. Sterile Filtered colorless solution.
产品种类 :
重组&NATURAL PROTEINS;重组蛋白
产品描述 :
Description: Smac/Diablo Human Recombinant fused to N-terminal T7-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids and having a molecular mass of 22 kDa. Introduction: Smac/Diablo is a proapoptotic protein that increases caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by its binding to the inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. Smac/Diablo is a mitochondrial protein which enters the cytosol when cells go through apoptosis, and it moderates the caspase inhibition of IAPs.Smac/DIABLO expression is associated with the result of renal cell carcinoma.Dimeric form of Smac/DIABLO implies that once expressed in the cell the protein has a little probability of dissociation and, thus, loss of function. Survivin, Smac/DIABLO, & PKC-? play an important part in the inhibition of apoptosis by FGF-2 in human small cell lung cancer cells. Mitochondrial survivin associates with Smac/DIABLO, delaying its release. Decreased expression of Smac protein takes part in ovarian carcinogenesis and chemotherapeutic resistance. Smac/DIABLO plays a role in tumor cells during the pathway of apoptosis induction. SMAC protein is regulated by XIAP and degraded by proteasome. SMAC protein takes part inleukemic cell apoptosis. Smac is released during stress-induced apoptosis in multiple myeloma cells.
NCBI GI登录号 :
508083041
NCBI登录号 :
NP_001265231.1
NCBI基因登录号 :
NM_001278302.1
UniProt数据库登录号 :
Q9NR28
NCBI分子量 :
22,284 Da
NCBI信号通路 :
Apoptosis Pathway 198797!!Apoptosis Pathway 105648!!Apoptosis Modulation And Signaling Pathway 198822!!Apoptotic Factor-mediated Response Pathway 105669!!Caspase Cascade In Apoptosis Pathway 137974!!Intrinsic Pathway For Apoptosis 105656!!Programmed Cell Death Pathway 1127510!!Release Of Apoptotic Factors From The Mitochondria Pathway 105668!!SMAC Binds To IAPs Pathway 105674!!SMAC-mediated Apoptotic Response Pathway 105673
NCBI总结 :
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
规格 :
0.02毫克
价格 :
205美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。