蛋白

Recombinant Human Ketohexokinase

MBS143682

1毫克

2220美元

重组蛋白

Recombinant Human Ketohexokinase

Ketohexokinase

Ketohexokinase Human; Ketohexokinase Human Recombinant; KHK; Hepatic Fructokinase; Ketohexokinase; Fructokinase; Ketohexokinase

ketohexokinase isoform a; Ketohexokinase; ketohexokinase; hepatic fructokinase; ketohexokinase (fructokinase); Hepatic fructokinase

KHK;KHK

KHK_HUMAN

大肠杆菌

298

MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV

Greater than 90.0% as determined by SDS-PAGE.

The protein solution contains 1xPBS, pH 7.4 and 10% glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

蛋白KINASES;酶;蛋白激酶

Description: Ketohexokinase Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids and having a molecular mass of 32.7 kDa. Introduction: Ketohexokinase catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, resulting in the utilization of ATP and creation of AMP. Ketohexokinase commences initial step in the metabolism of dietary fructose and is a significant regulator of hepatic glucose metabolism. Ketohexokinase is found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. ketohexokinase plays an unknown physiologic function that remains intact in essential fructosuria. Ketohexokinase expression is reduceed in human clear cell type of renal cell carcinoma.

4557693

NP_000212.1

NM_000221.2

P50053

32,523 Da

Disease Pathway 530764!!Fructose And Mannose Metabolism Pathway 82930!!Fructose And Mannose Metabolism Pathway 291!!Fructose Catabolism Pathway 106218!!Glycogen Storage Diseases Pathway 1127581!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Carbohydrates Pathway 106196!!Myoclonic Epilepsy Of Lafora Pathway 1127582!!Polyol Pathway 198815

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

1毫克

2220美元