APC4抗体 | MyBioSource MBS150295 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

APC4抗体

MBS150295

规格 :

0.1毫克

价格 :

345美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

更多信息或购买 :

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产品信息

目录号 :

MBS150295

产品类型 :

抗体

产品全称 :

APC4抗体

产品简称 :

APC4

产品名称同义词 :

APC4; APC4; APC4; Anaphase-promoting complex subunit 4; Cyclosome subunit 4; anaphase promoting complex subunit 4

其他名称 :

Anaphase-promoting complex subunit 4; Anaphase-promoting complex subunit 4; anaphase-promoting complex subunit 4; cyclosome subunit 4; anaphase promoting complex subunit 4; Cyclosome subunit 4

产品基因名称 :

ANAPC4

其他基因名称 :

ANAPC4;ANAPC4;APC4;APC4;APC4

UniProt数据库进入名 :

APC4_HUMAN

克隆性 :

多克隆

抗体亚型 :

IgG

宿主 :

兔

反应物种 :

人类, 小鼠, 大鼠

序列长度 :

808

纯度 :

APC4 Antibody is affinity chromatography purified via peptide column.

形式 :

液体

浓度 :

1毫克/毫升

储存稳定性 :

APC4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

检测过的应用 :

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

应用笔记 :

APC4 antibody can be used for detection of APC4 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

其它信息1 :

Conjugate: Unconjugated. Immunogen: APC4 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human APC4. Buffer: APC4 Antibody is supplied in PBS containing 0.02% sodium azide.

产品描述 :

APC4 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC4 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC4, it is thought that APC4 associates with other APC/C components APC1, APC5, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.

NCBI GI登录号 :

205371737

NCBI登录号 :

Q9UJX5.2

UniProt数据库登录号 :

Q9UJX5

NCBI分子量 :

92,216 Da

NCBI信号通路 :

APC-Cdc20 Mediated Degradation Of Nek2A Pathway (1127551); APC/C Complex Pathway (413481); APC/C Complex Pathway (468395); APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway (105832); APC/C:Cdc20 Mediated Degradation Of Securin Pathway (105833); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105831); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (105835); APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway (1127549); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105829)

NCBI总结 :

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

UniProt数据库总结 :

APC4: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11 -linked polyubiquitin chains and, to a lower extent, the formation of Lys-48 - and Lys-63 -linked polyubiquitin chains. Belongs to the APC4 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 4p15.2. Cellular Component: nucleoplasm; anaphase-promoting complex; nucleus; cytosol. Molecular Function: protein binding; ubiquitin-protein ligase activity; protein phosphatase binding. Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle

尺寸1 :

0.1毫克

价格1 :

345美元

更多信息或购买 :

MyBioSource 产品网页

公司信息