抗体

DARC抗体

MBS150798

0.1毫克

345美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

DARC抗体

DARC

DARC; FY; Dfy; GPD; GpFy; ACKR1; CCBP1; CD234; WBCQ1; FY; Atypical chemokine receptor 1; Duffy blood group, chemokine receptor

Atypical chemokine receptor 1; Atypical chemokine receptor 1; atypical chemokine receptor 1; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; Duffy blood group, chemokine receptor; Duffy blood group, atypical chemokine receptor; atypical chemokine receptor 1 (Duffy blood group); Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234

DARC

ACKR1; ACKR1; FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1; DARC; FY; GPD; GpFy

ACKR1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

336

DARC Antibody is affinity chromatography purified via peptide column.

Liquid

1毫克/毫升

DARC antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

DARC antibody can be used for detection of DARC by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.

Conjugate: Unconjugated. Immunogen: DARC antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human DARC. Buffer: DARC Antibody is supplied in PBS containing 0.02% sodium azide.

DARC Antibody: DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.

67476970

Q16570.3

Q16570

35,678 Da

Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!GPCR Ligand Binding Pathway 161020!!GPCRs, Other Pathway 198765!!Malaria Pathway 152665!!Malaria Pathway 152657!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637!!Peptide GPCRs Pathway 198897!!Peptide Ligand-binding Receptors Pathway 106358

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.1毫克

345美元