抗体

TRPC6抗体

MBS150882

0.1毫克

345美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法

抗体

TRPC6抗体

TRPC6

TRPC6; TRP6; FSGS2; TRP6; Short transient receptor potential channel 6; Transient receptor protein 6; TrpC6; transient receptor potential cation channel, subfamily C, member 6

Transient receptor potential cation channel, subfamily C, member 6; Short transient receptor potential channel 6; short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6

TRPC6

TRPC6;TRPC6;TRP6;FSGS2;TRP6;TrpC6;TRP-6

TRPC6_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

931

This antibody may cross-react with TRPC3.

TRPC6 Antibody is affinity chromatography purified via peptide column.

液体

1毫克/毫升

TRPC6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF)

TRPC6 antibody can be used for the detection of TRPC6 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: TRPC6 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TRPC6. Buffer: TRPC6 Antibody is supplied in PBS containing 0.02% sodium azide.

TRPC6 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.

62739910

AAH93658

Q9Y210

Predicted: 100; 102 kDa. Observed: 93 kDa

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EPO Signaling Pathway (138051); Effects Of PIP2 Hydrolysis Pathway (106044); Elevation Of Cytosolic Ca2+ Levels Pathway (106047); Endothelins Pathway (137958); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Hemostasis Pathway (106028)

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11q22.1. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; store-operated calcium channel activity. Biological Process: positive regulation of ion transmembrane transporter activity; platelet activation; axon guidance; elevation of cytosolic calcium ion concentration; blood coagulation; positive regulation of calcium ion transport; transmembrane transport; cation transport; aging. Disease: Focal Segmental Glomerulosclerosis 2

0.1毫克

345美元