抗体

抗NF200抗体(单克隆)

MBS175078

0.1毫克

245美元

单克隆

小鼠

未共轭

NF-200

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

抗体

抗NF200抗体(单克隆)

NF200

Neurofilament heavy polypeptide; neurofilament, heavy polypeptide; NFH; KIAA0845; 200 kDa neurofilament protein; Neurofilament triplet H protein

Neurofilament heavy polypeptide; Neurofilament heavy polypeptide; neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa; neurofilament, heavy polypeptide; 200 kDa neurofilament protein; Neurofilament triplet H protein

NEFH

NEFH;NEFH;NFH;KIAA0845;NFH;NF-H

NFH_HUMAN

单克隆

IgG1

NF-200

小鼠

人类, 小鼠, 大鼠

1026

腹水

冻干

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

免疫印迹(免疫印迹), 免疫组化(免疫组化)石蜡, 免疫组化(免疫组化)福尔马林

Immunogen: C-terminal segment of enzymatically dephosphorylated pig Neurofilament 200.

Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Description: Mouse IgG monoclonal antibody for NF200, neurofilament, heavy polypeptide (NEFH) detection. Tested with WB, IHC-P, IHC-F in Human, mouse, rat. No cross reactivity with other proteins. Uniprot ID: P12036. Background: Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 kD(NFL), 125 kD(NFM), and 200 kD(NFH) on SDS-gel electrophoresis. Genomic clones for the largest human neurofilament protein(NF-H) were isolated, the intron/exon boundaries mapped and the entire protein-coding regions(exons) sequenced. mutations in neurofilaments have been linked to some forms of Charcot-Marie-Tooth disease(CMT).

226726294

P12036.4

P12036

105,639 Da

肌萎缩性侧索硬化症 (ALS)通路(920975);肌萎缩性侧索硬化症 (ALS)通路(83099);肌萎缩性侧索硬化症 (ALS)通路(511)

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]

NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 22q12.2. Cellular Component: mitochondrion; axon; cytoplasm; neurofilament. Molecular Function: protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding. Biological Process: axonogenesis; neurofilament bundle assembly; microtubule cytoskeleton organization and biogenesis; cell projection biogenesis; peripheral nervous system neuron axonogenesis. Disease: Amyotrophic Lateral Sclerosis 1

0.1毫克

245美元