抗体

多克隆抗GJA5抗体

MBS175364

0.1毫克

245美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

抗体

多克隆抗GJA5抗体

GJA5

间隙连接甲5蛋白;间隙接头蛋白, 甲5, 40kDa;连接蛋白40抗体;连接蛋白40抗体;Cx40抗体;CXA5_HUMAN抗体;间隙连接甲5蛋白抗体;间隙连接甲5蛋白抗体;间隙接头蛋白甲5 40kD(连接蛋白40)抗体;间隙接头蛋白甲5抗体;GJA5抗体;MGC11185抗体

间隙连接甲5蛋白;间隙连接甲5蛋白;间隙连接甲5蛋白;连接蛋白40;间隙接头蛋白甲5 40kDa;间隙接头蛋白, 甲5, 40kDa;连接蛋白40;Cx40

GJA5

GJA5;GJA5;CX40;ATFB11;Cx40

CXA5_HUMAN

多克隆

兔IgG

兔

Reacts with: Human, Mouse, Rat

358

No cross reactivity with other proteins.

免疫原亲和纯化

冻干

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

免疫印迹(免疫印迹), 免疫组化(免疫组化)石蜡

Western Blot:. Concentration: 0.1-0.5 ug/ml. Tested Species: Ms . Predicted Species: Hu, Rat. Antigen Retrieval: -. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1 ug/ml. Tested Species: Hu, Rat . Predicted Species: Ms. Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by the end users.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Connexin 40/GJA5 (341-358aa KRRLSKASSKARSDDLSV), identical to the related mouse and rat sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Gap junction alpha-5 protein(GJA5) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: Connexin proteins oligomerize to form intercellular channels, called gap junctions, through which ions and small molecules move between adjacent cells. Connexin 40(Gap junction alpha-5 protein) is a protein that in humans is encoded by the GJA5 gene.This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.

8928556

P36382.3

P36382

40,380 Da

Calcium Regulation In The Cardiac Cell Pathway (198906); Gap Junction Assembly Pathway (105928); Gap Junction Trafficking Pathway (105927); Gap Junction Trafficking And Regulation Pathway (105926); Membrane Trafficking Pathway (106160)

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]

GJA5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA5 are a cause of familial atrial standstill (FAS). Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Defects in GJA5 are the cause of familial atrial fibrillation type 11 (ATFB11). ATFB11 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the connexin family. Alpha-type (group II) subfamily. Protein type: Channel, misc.; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q21.1. Cellular Component: connexon complex; cell projection; integral to plasma membrane; gap junction. Molecular Function: gap junction hemi-channel activity. Biological Process: gap junction assembly; negative regulation of glomerular filtration; positive regulation of vasodilation; protein oligomerization; positive regulation of vasoconstriction; artery morphogenesis; embryonic heart tube development; negative regulation of blood pressure; angiogenesis; skeletal development; transmembrane transport; potassium ion transport; embryonic limb morphogenesis. Disease: Atrial Standstill 1; Atrial Fibrillation, Familial, 11

0.1毫克

245美元