抗体

抗CD34抗体

MBS175400

0.1毫克

245美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

抗体

抗CD34抗体

CD34

Hematopoietic progenitor cell antigen CD34; CD34 molecule; CD34 antibody; Cd34 antibody; CD34 antigen antibody; CD34 molecule antibody; CD34_HUMAN antibody; Cluster designation 34 antibody; Hematopoietic progenitor cell antigen CD34 antibody; HPCA1 antibody; Mucosialin antibody; OTTHUMP00000034733 antibody; OTTHUMP00000034734 antibody

造血祖细胞抗原CD34;造血祖细胞抗原CD34;造血祖细胞抗原CD34;CD34抗原;CD34分子;CD_antigen:CD34

CD34

CD34;CD34

CD34_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

385

免疫原亲和纯化

冻干

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

免疫印迹(免疫印迹), 免疫组化(免疫组化)石蜡, 免疫组化(免疫组化)福尔马林

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CD34 (366-382aa QATSRNGHSARQHVVAD), identical to the related mouse and rat sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Hematopoietic progenitor cell antigen CD34(CD34) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat. Background: CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 KD.CD34 is expressed in humans in hematopoietic stem cells, vascular endothelium, and blasts from 30% of patients with acute myeloid and lymphocytic leukemia. The human CD34 gene spans 26 kb and has 8 exons, a structure quite similar to that of the murine gene. By Southern blot analysis of DNA from a panel of human x mouse somatic cell hybrids using a CD34 cDNA probe demonstrate that the gene for CD34 is located on human chromosome 1 in the 1q12----qter region. CD34 plays an important role in the formation of progenitor cells during both embryonic and adult hematopoiesis.

3183511

P28906.2

P28906

35,011 Da

Adaptive Immune System Pathway (366160); C-MYB Transcription Factor Network Pathway (138073); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)

The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: intercellular bridge; integral to plasma membrane; lysosome; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding. Biological Process: positive regulation of odontogenesis; regulation of immune response; negative regulation of nitric oxide biosynthetic process; glomerular filtration; cell motility involved in cell locomotion; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-10 production; cell proliferation; cell-cell adhesion; positive regulation of angiogenesis; endothelial cell proliferation; regulation of blood pressure; tissue homeostasis; hemopoiesis; leukocyte migration

0.1毫克

245美元